c-MET NSCLC FDA Approvals, Clinical Trials Assessment, Pipeline Insights, and Companies | DelveInsight

DelveInsight's, "C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Pipeline Insight" report provides comprehensive insights about 20+ companies and 20+ pipeline drugs in C-MET Non-Small Cell Lung Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the c-MET-NSCLC Pipeline Report

* In January 2025:- AbbVie:- A Phase 3 Open-Label, Randomized, Controlled, Global Study of Telisotuzumab Vedotin (ABBV-399) Versus Docetaxel in Subjects With Previously Treated c-Met Overexpressing, EGFR Wildtype, Locally Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer.
* DelveInsight's c-MET-NSCLC pipeline report depicts a robust space with 20+ active players working to develop 20+ pipeline therapies for c-MET-NSCLC treatment.
* The leading c-MET-NSCLC Companies such as AbbVie, Janssen Research & Development, Beijing Pearl Biotechnology Limited Liability Company, Novartis , and others.
* Promising C-MET NSCLC Therapies such as Glumetinib, Tepotinib, INC280, APL-101 Oral Capsules, MCLA-129, Osimertinib , and others.

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c-MET NSCLC Emerging Drugs Profile

* JNJ-61186372: Janssen Research & Development, LLC

JNJ-6372 is an EGFR-MET bispecific antibody with immune cell-directing activity that targets activating and resistant EGFR and MET mutations and amplifications. The production and development of the antibody followed Janssen's licensing agreement with Genmab for use of its DuoBody technology platform. According to the company, JNJ-6372 is a novel bispecific antibody that has the potential to benefit patients with Exon 20 mutation insertions who often do not respond to currently available oral EGFR-targeted or immune checkpoint inhibitor therapies.

* PLB1001 - Beijing Pearl Biotechnology Limited Liability Company

PLB1001 is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor; HGFR) with potential antineoplastic activity. Upon administration, PLB1001 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.

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c-MET NSCLC Companies

AbbVie, Janssen Research & Development, Beijing Pearl Biotechnology Limited Liability Company, Novartis, and others.

C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

* Oral
* Intramuscular
* Intratumoral
* Intravenous
* Molecule Type

c-MET NSCLC Products have been categorized under various Molecule types such as

* Gene therapies
* Bispecific antibodies
* Immunotherapies
* Monoclonal antibodies
* Small molecules
* Product Type

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Scope of the c-MET NSCLC Pipeline Report

* Coverage- Global
* c-MET NSCLC Companies- AbbVie, Janssen Research & Development, Beijing Pearl Biotechnology Limited Liability Company, Novartis, and others.
* C-MET NSCLC Therapies- Glumetinib, Tepotinib, INC280, APL-101 Oral Capsules, MCLA-129, Osimertinib, and others.
* c-MET NSCLC Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
* c-MET NSCLC Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

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Table of Content

* Introduction
* Executive Summary
* C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC): Overview
* Pipeline Therapeutics
* Therapeutic Assessment
* C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) - DelveInsight's Analytical Perspective
* In-depth Commercial Assessment
* C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Collaboration Deals
* Mid Stage Products (Phase II)
* Telisotuzumab: AbbVie
* PLB1001: Beijing Pearl Biotechnology Limited Liability Company
* Drug profiles in the detailed report.....
* Early Stage Products (Phase I)
* JNJ-61186372: Janssen Research & Development, LLC
* Drug profiles in the detailed report.....
* Pre-clinical and Discovery Stage Products
* Drug profiles in the detailed report.....
* Inactive Products
* C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Key Companies
* C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Key Products
* C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC)- Unmet Needs
* C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC)- Market Drivers and Barriers
* C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC)- Future Perspectives and Conclusion
* C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Analyst Views
* C-MET Non-Small Cell Lung Cancer (C-MET+ NSCLC) Key Companies
* Appendix

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