Press release
Von Hippel-Lindau Market Size to Exhibit Moderate Growth by 2034, Evaluates DelveInsight
Von Hippel-Lindau Drugs Market
Discover Key Insights into the Von Hippel-Lindau Market with DelveInsight's In-Depth Report @ Von Hippel-Lindau Market Size- https://www.delveinsight.com/sample-request/von-hippel-lindau-disease-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Key Takeaways from the Von Hippel-Lindau (VHL) Disease Market Report
• Among the 7MM, the United States accounted for the highest number of total prevalent cases of Von Hippel-Lindau disease, i.e. ~9,500 in 2023.
• In EU4 and the UK, Germany accounted for the highest number of total Diagnosed cases of Von Hippel-Lindau disease, whereas Spain accounts for the lowest, in 2023.
• In 2023, in the US, the most prevalent clinical manifestation-specific cases of Von Hippel-Lindau disease in the United States were attributed to retinal hemangioblastomas, making up approximately ~21% of the cases.
• The leading Von Hippel-Lindau (VHL) Disease Companies such as Roche, Exelixis, Bayer, Novartis, and others.
• Promising Von Hippel-Lindau (VHL) Disease Therapies such as Belzutifan, and others.
Stay ahead in the Von Hippel-Lindau Therapeutics Market with DelveInsight's Strategic Report @ Von Hippel-Lindau Market Outlook- https://www.delveinsight.com/sample-request/von-hippel-lindau-disease-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Von Hippel-Lindau (VHL) Disease Epidemiology Insights in the 7MM
• Total Von Hippel-Lindau Prevalent cases
• Total Von Hippel-Lindau Diagnosed cases
• Von Hippel-Lindau Clinical Manifestation-specific cases
• Total Von Hippel-Lindau treated cases
Download the report to understand which factors are driving Von Hippel-Lindau epidemiology trends @ Von Hippel-Lindau Prevalence- https://www.delveinsight.com/sample-request/von-hippel-lindau-disease-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Von Hippel-Lindau Disease Marketed Drugs
• WELIREG (belzutifan): Merck
WELIREG (belzutifan), developed by Merck, received FDA approval in August 2021. It's indicated for adult Von Hipple-Lindau patients with renal cell carcinoma, CNS hemangioblastomas, or pancreatic neuroendocrine tumors not immediately needing surgery. Belzutifan inhibits HIF-2α, a key factor in oxygen sensing and gene regulation under hypoxia. By binding to HIF-2α, belzutifan disrupts its interaction with HIF-1β, reducing the expression of genes linked to proliferation, angiogenesis, and tumor growth. WELIREG approval was supported by LITESPARK-004 (NCT03401788), an open-label trial involving 61 Von Hipple-Lindau disease associated RCC patients with a documented Von Hipple-Lindau disease germline alteration and at least one measurable kidney tumor according to RECIST v1.1 criteria.
Emerging Von Hippel-Lindau Disease Drugs
• DFF332: Novartis
DFF332 is a small molecule being developed by Novartis as a single agent and in combination in patients with advanced clear cell renal cell carcinoma and other malignancies with HIF stabilizing mutations. The development in combination includes Everolimus (RAD001, an mTOR inhibitor), and also in combination with Spartalizumab (PDR001, an anti-PD1) plus Taminadenant (NIR178, an adenosine A2A receptor antagonist). DFF332 targets a protein called HIF2α; by acting on HIF2α, DFF332 may stop the growth of certain types of cancer. DFF332 is currently being evaluated in a clinical Phase I trial to treat advanced/relapsed ccRCC and other malignancies with HIF2α stabilizing mutations.
Get In-Depth Knowledge on Von Hippel-Lindau Market Trends and Forecasts with DelveInsight @ Von Hippel-Lindau Treatment Market- https://www.delveinsight.com/sample-request/von-hippel-lindau-disease-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Von Hippel-Lindau (VHL) Disease Drugs Market
The existing Von Hippel-Lindau Disease treatment is mainly dominated by Hypoxia-inducible factor-2α (HIF-2α) inhibitor. Belzutifan is an inhibitor of hypoxia-inducible factor 2 alpha (HIF-2α). HIF-2α is a transcription factor that plays a role in oxygen sensing by regulating genes that promote adaptation to hypoxia. Under normal oxygen levels, HIF-2α is targeted for ubiquitin-proteasomal degradation by Von Hipple-Lindau disease protein.
Von Hippel-Lindau Disease Market Outlook
For patients who have Von Hippel-Lindau disease, the goal of treatment is cancer control, not to cure cancer, and preservation of functional parenchyma to avoid the morbidity associated with renal or adrenal loss. Primary treatment of all Von Hippel-Lindau disease related tumors is local (i.e., surgical resection, RFA, radiotherapy). However, repeated local interventions at multiple sites or repeated recurrences in one area can increase morbidity. Therefore, in individual patients, systemic treatment may be an option.
Unlock Strategic Insights with DelveInsight's Comprehensive Von Hippel-Lindau Market Report @ Von Hippel-Lindau Market Drivers and Barriers- https://www.delveinsight.com/sample-request/von-hippel-lindau-disease-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Scope of the Von Hippel-Lindau (VHL) Disease Market Report
• Coverage- 7MM
• Study Period- 2020-2034
• Von Hippel-Lindau (VHL) Disease Companies- Roche, Exelixis, Bayer, Novartis, and others.
• Von Hippel-Lindau (VHL) Disease Therapies- Belzutifan, and others.
• Von Hippel-Lindau (VHL) Disease Market Dynamics: Von Hippel-Lindau (VHL) Disease Market drivers and Von Hippel-Lindau (VHL) Disease Market Barriers
• Von Hippel-Lindau (VHL) Disease Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
• Von Hippel-Lindau (VHL) Disease Unmet Needs, KOL's views, Analyst's views, Von Hippel-Lindau (VHL) Disease Market Access and Reimbursement
Table of Content
1 Key Insights
2 Report Introduction
3 Executive Summary
4 Key Events
5 Epidemiology and Market Forecast Methodology
6 Von Hippel-Lindau disease Market Overview at a Glance
7 Disease Background and Overview
8 Treatment and Management
9 Epidemiology and Patient Population
10 Patient Journey
11 Marketed Therapies
12 Emerging Therapies
13 Von Hippel-Lindau Disease: 7 Major Market Analysis
14 Unmet Needs
15 SWOT Analysis
16 KOL Views
17 Market Access and Reimbursement
18 Appendix
19 DelveInsight Capabilities
20 Disclaimer
21 About DelveInsight
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About Us
DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.
Company Name: DelveInsight Business Research LLP
Contact Person: Yash Bhardwaj
Email: ybhardwaj@delveinsight.com
Phone: 09650213330
Address: 304 S. Jones Blvd #2432
City: Las Vegas
State: NV
Country: United States
Website: https://www.delveinsight.com/
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