Janus Kinase Inhibitor Pipeline Insights, Clinical Trials Assessment, FDA Approvals, Emerging Drugs and Companies | DelveInsight

DelveInsight's, "Janus Kinase Inhibitor Pipeline Insight" report provides comprehensive insights about 50+ companies and 55+ pipeline drugs in Janus Kinase (JAK) Inhibitor pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the Janus Kinase Inhibitor Pipeline Report
• In January 2025:- AstraZeneca:- This is a Phase 2a, multicentre, randomised, placebo-controlled, double-blind, parallel-group study to evaluate the efficacy, safety and PK of AZD4604 administered BID using a dry-powder inhaler at one dose level over a 12-week Treatment period in adult participants with uncontrolled moderate-to-severe asthma.
• In January 2025:- Sanofi:- A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, 3-arm, Multinational, Multicenter Study to Evaluate the Efficacy and Safety of Amlitelimab by Subcutaneous Injection in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis (AD) Who Are on Background Topical Corticosteroids and Have Had an Inadequate Response to Prior Biologic Therapy or Oral Janus Kinase (JAK) Inhibitor Treatment
• In January 2025:- Celgene:- The purpose of this Phase 3 study is to evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative neoplasm (MPN)-associated Myelofibrosis (MF) and anemia on concomitant Janus kinase 2 (JAK2) inhibitor therapy and who require red blood cell count (RBC) transfusions.
• DelveInsight's Janus Kinase Inhibitor pipeline report depicts a robust space with 50+ active players working to develop 55+ pipeline therapies for Janus Kinase Inhibitor treatment.
• The leading Janus Kinase Inhibitor Companies such as Incyte Corporation, Celon Pharma, Aclaris Therapeutics, Sareum, Takeda, AstraZeneca, Incyte Corporation, Ajax Therapeutics, Pfizer, GSK, Dizal Pharmaceutical, Confluence Life Sciences, Celon Pharma, Incyte Corporation, Arcutis, Biotherapeutics/Reistone Biopharma, and others.
• Promising Janus Kinase Inhibitor Therapies such as Abrocitinib 200 MG Oral Tablet, Ritlecitinib, TL-895, KRT-232, Selinexor 60 mg, Navtemadlin, Ruxolitinib, Imetelstat, and others.

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Janus Kinase Inhibitor Emerging Drugs Profile
• Povorcitinib: Incyte Corporation
Povorcitinib (INCB054707) is an oral small-molecule JAK1 inhibitor. The chemical structure for povorcitinib was revealed in WHO proposed INN list 126 (Jan 2022), in which it was described as a Janus kinase inhibitor and anti-inflammatory agent. The drug is also being evaluated in Phase II clinical trials for Prurigo Nodularis, and others. Currently, the drug is in Phase III stage of its development for the treatment of Hidradenitis suppurativa, vitiligo.

• CPL409116: Celon Pharma
CPL 409116 is the first in class dual JAK/ROCK inhibitor in clinical development and is designed to generate anti-inflammatory and anti-fibrotic effects in selected autoimmune diseases. CPL'116 was administered orally in single ascending doses in healthy volunteers in order to assess safety and pharmacokinetic parameters (PK). No adverse events associated with administration of the investigational drug were observed, and the trial met its primary endpoint. Currently the drug is in Phase II stage of development for autoimmune indications including in patients with rheumatoid arthritis with coexisting interstitial lung disease.

• ATI-2138: Aclaris Therapeutics
ATI-2138 is an investigational oral covalent ITK/JAK3 inhibitor that is being developed as a potential therapeutic option across a variety of T cell-mediated diseases. ITK is a T cell receptor activated kinase involved in driving T cell effector functions while JAK3 is a non-receptor tyrosine kinase responsible for the signal transduction of common gamma receptor cytokines, IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. In blocking both T cell receptor function and cytokine signaling, ATI-2138 has potential utility in T cell driven diseases. ATI-2138 is currently in clinical development and its safety and efficacy has not been evaluated by regulatory authorities.

• SDC 1802: Sareum
SDC-1802 is an investigational Sareum's TYK2/JAK1 preclinical development candidate molecule that demonstrates high selectivity for TYK2 and JAK1 kinases (particularly over related JAK2 and JAK3). SDC-1802 shows compelling efficacy in blocking cancer cell proliferation in cellular and disease models of T-cell acute lymphoblastic leukaemia (T-ALL) and B-cell lymphoma, the potential for once-daily oral dosing and a good early safety profile. Sareum is progressing SDC-1802 through preclinical development and pending satisfactory progress, into human clinical trials. SDC-1802 has the potential to act as a back-up molecule for these autoimmune indications. Currently, the drug is in Preclinical stage of its development for the treatment of cancer.

Learn more about Janus Kinase Inhibitor Drugs opportunities in our groundbreaking Janus Kinase Inhibitor Research and development projects @ Janus Kinase Inhibitor Unmet Needs- https://www.delveinsight.com/sample-request/janus-kinase-jak-inhibitor-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Janus Kinase Inhibitor Companies
Incyte Corporation, Celon Pharma, Aclaris Therapeutics, Sareum, Takeda, AstraZeneca, Incyte Corporation, Ajax Therapeutics, Pfizer, GSK, Dizal Pharmaceutical, Confluence Life Sciences, Celon Pharma, Incyte Corporation, Arcutis, Biotherapeutics/Reistone Biopharma, and others.

Janus Kinase (JAK) Inhibitor pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical

Janus Kinase Inhibitor Products have been categorized under various Molecule types such as
• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy

Discover the latest advancements in Janus Kinase Inhibitor treatment by visiting our website. Stay informed about how we're transforming the future of disease @ Janus Kinase Inhibitor Market Drivers and Barriers, and Future Perspectives- https://www.delveinsight.com/sample-request/janus-kinase-jak-inhibitor-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Scope of the Janus Kinase Inhibitor Pipeline Report
• Coverage- Global
• Janus Kinase Inhibitor Companies- Incyte Corporation, Celon Pharma, Aclaris Therapeutics, Sareum, Takeda, AstraZeneca, Incyte Corporation, Ajax Therapeutics, Pfizer, GSK, Dizal Pharmaceutical, Confluence Life Sciences, Celon Pharma, Incyte Corporation, Arcutis, Biotherapeutics/Reistone Biopharma, and others.
• Janus Kinase Inhibitor Therapies- Abrocitinib 200 MG Oral Tablet, Ritlecitinib, TL-895, KRT-232, Selinexor 60 mg, Navtemadlin, Ruxolitinib, Imetelstat, and others.
• Janus Kinase Inhibitor Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• Janus Kinase Inhibitor Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

For a detailed overview of our latest research findings and future plans, read the full details of Janus Kinase Inhibitor Pipeline on our website @ Janus Kinase Inhibitor Emerging Drugs and Companies- https://www.delveinsight.com/sample-request/janus-kinase-jak-inhibitor-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Table of Content
1. Introduction
2. Executive Summary
3. Janus Kinase (JAK) Inhibitor: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Janus Kinase (JAK) Inhibitor- DelveInsight's Analytical Perspective
7. Late Stage Products (Phase III)
8. Povorcitinib: Incyte Corporation
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. CPL409116: Celon Pharma
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. ATI-2138: Aclaris Therapeutics
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. SDC 1802: Sareum
18. Drug profiles in the detailed report…..
19. Inactive Products
20. Janus Kinase (JAK) Inhibitor Key Companies
21. Janus Kinase (JAK) Inhibitor Key Products
22. Janus Kinase (JAK) Inhibitor- Unmet Needs
23. Janus Kinase (JAK) Inhibitor- Market Drivers and Barriers
24. Janus Kinase (JAK) Inhibitor- Future Perspectives and Conclusion
25. Janus Kinase (JAK) Inhibitor Analyst Views
26. Janus Kinase (JAK) Inhibitor Key Companies
27. Appendix

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