Press release
Protein Expression Market Set to Soar Amid Growing Biopharma Production
The protein expression market is expected to grow from an estimated USD 3514.5 million in 2024 to USD 8702.8 million in 2033, at a CAGR of 10.60%. The protein expression market is poised for significant growth, driven by increased production capacities within the biopharmaceutical industry. With biosimilars gaining traction in treating rare diseases, autoimmune disorders, and cancer, their cost advantages and regulatory support are fueling demand. The COVID-19 pandemic also spurred the expansion of vaccine manufacturing facilities, further boosting the market.Key Drivers:
Biopharmaceutical Expansion: Companies are ramping up production to meet the rising demand for biosimilars. For example, Thermo Fisher Scientific Inc. expanded its facilities in Cincinnati, Ohio, and Bend, Oregon, in October 2024 to support oral drug development.
Demand for Biologics: The increasing need for biologics, such as monoclonal antibodies and antibody-drug conjugates, is driving market growth. In 2023, the US FDA approved 17 new biologics, including 12 monoclonal antibodies.
Emerging Economies: Nations like China, India, Brazil, and Mexico are experiencing growth in the biopharmaceutical sector due to public and private investments, making them attractive markets for protein expression systems.
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Market Restraints: Efficiency issues and high production costs pose challenges. Bacterial systems, though cost-effective, can lead to difficult-to-purify protein clumps. Yeast and mammalian systems, while effective, face high production costs and lower expression levels. Plant-based systems are limited by concerns over gene and protein spread into the food chain.
Segment Insights:
Prokaryotic Systems: Leading the market with features like cost-effective and large-scale recombinant protein production.
Mammalian Systems: Expected to grow at the highest rate, driven by pharmaceutical companies using these systems for protein production. Innovations like ProteoGenix's XtenCHOTM Transient Expression System are enhancing protein yields and speeding up drug screening processes.
The protein expression market is on an upward trajectory, supported by the biopharmaceutical industry's expansion and increasing demand for biologics. Despite some challenges, the market holds significant growth potential, particularly in emerging economies.
Protein Expression Top Companies and Competitive Landscape
Agilent Technologies, Inc., Bio-Rad Laboratories, Thermo Fisher Scientific, Inc., and Merck Millipore are some key companies to watch out for innovation in the protein expression market. Key players operating in the market are adopting various strategies to increase their market presence and expand their product portfolio.
In April 2024, Expression Systems collaborated with Thomson to demonstrate how Expression Systems' ESF AdvanCD cell culture medium and Thomson's Optimum Growth flasks may improve protein output. This collaboration showed steady cell growth and high expression levels in a range of flask sizes and culture volumes, suggesting a dependable and expandable production platform.
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Some of the key companies in the global Protein Expression Market include:
Agilent Technologies, Inc.
Bio-Rad Laboratories
Thermo Fisher Scientific, Inc.
Merck Millipore
New England BioLabs, Inc.
Promega Corporation
QIAGEN
Takara Bio, Inc.
Oxford Expression Technologies
Lucigen Corporation
Protein Expression Latest Industry Updates
In June 2024, Thermo Fisher Scientific, Inc. launched the Thermo Scientific Stellar mass spectrometer (MS), which supports translational omics research with high throughput operations.
In August 2024, Merck KGaA acquired Mirus Bio to integrate its cutting-edge transfection reagents into its bioprocessing portfolio and enhance its capacity to manufacture viral vectors.
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Protein Expression Market Segmentation Analysis
Systems Outlook (Revenue, USD Million; 2020-2033)
Prokaryotic
Insect Cell
Yeast
Mammalian Cell
Others
Product Outlook (Revenue, USD Million; 2020-2033)
Reagents
Expression Vectors
Instruments
Competent Cells
Services
Application Outlook (Revenue, USD Million; 2020-2033)
Research
Therapeutic
Industrial
End User Outlook (Revenue, USD Million; 2020-2033)
Contract Research Organizations
Pharmaceutical and Biotechnological Companies
Academic Research
Others
Regional Outlook (Revenue, USD Million; 2020-2033)
North America
United States
Canada
Mexico
Europe
Germany
France
United Kingdom
Italy
Spain
Benelux
Rest of Europe
Asia-Pacific
China
India
Japan
South Korea
Rest of Asia-Pacific
Latin America
Brazil
Rest of Latin America
Middle East and Africa
Saudi Arabia
UAE
South Africa
Turkey
Rest of MEA
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