New Study on Frontier Pharma: Glioblastoma Multiforme - Cancer Immunotherapies Dominate First-in-Class Product Innovation
Glioblastoma multiforme (GBM) is a grade IV tumor that arises from astrocytes. It is the most common and aggressive human brain tumor, accounting for 15.4% of all primary brain tumors and 60-75% of all astrocytomas. It has a peak incidence between 55 and 84 years of age, with the median age of diagnosis being 64 years. In the US and EU, the annual incidence was estimated to be three to four cases per 100,000 people. GBM has a high degree of intratumoral heterogeneity, which is associated with poor prognosis and the development of drug resistance.
The GBM market is characterized by a small selection of marketed product options, consisting of chemotherapies, cancer immunotherapies and receptor tyrosine kinase inhibitor products. The pipeline is moderately large, with 512 products active across all stages of development. First-in-class products only constitute approximately a quarter of the pipeline, and represent 31% of products with a disclosed target. The most widely studied group of first-in-class targets are the receptor tyrosine kinase and ligand inhibitors, a trend that has been heavily influenced by the success of Avastin, and possibly successful EGFR inhibitors such as Tarceva that are used in the treatment of other oncology indications.
To Get Sample Copy of Report visit @ http://www.researchmoz.us/enquiry.php?type=S&repid=826604
Potential driving factors for the market include a typically poor outcome for treated patients, a growing patient pool if disease prognosis can be improved, a lack of approved options in the market, and a strong understanding of the disease pathophysiology that has developed over the last decade, facilitating the development of novel compounds that may fulfill the unmet needs.
Overall, due to the highly complex and polygenic nature of GBM, which has numerous subtype classifications, it is unlikely that the inhibition of a single target will be sufficient to substantially improve patient prognosis. Instead, it is more likely that the concurrent use of multiple targeted therapies, along with other available modes of therapy, may improve treatment outcomes. First-in-class targets analyzed in this report have shown encouraging efficacy profiles, and some show the ability to chemosensitize cancer cells.
The report analyzes innovation in GBM, in the context of the overall pipeline and current market landscape. In addition, it analyzes the deals landscape surrounding first-in-class products, and pinpoints opportunities for in-licensing.
A brief introduction to GBM, including symptoms, pathophysiology, and an overview of pharmacotherapy and treatment algorithms.
The changing molecular target landscape between the market and the pipeline, including particular focal points of innovation in the pipeline.
A comprehensive review of the pipeline for first-in-class therapies, analyzed on the basis of stage of development, molecule type and molecular target.
Identification and assessment of first-in-class molecular targets, with a particular focus on early-stage programs for which clinical utility has yet to be evaluated, as well as literature reviews on novel molecular targets.
Assessment of the licensing and co-development deal landscape for GBM therapies.
Reasons to buy
Understand the current clinical and commercial landscape, including a comprehensive study of disease pathogenesis, diagnosis, prognosis and the available treatment options.
Visualize the composition of the GBM market in terms of dominant molecule types and targets, highlighting what the current unmet needs are and how they can be addressed. This knowledge allows a competitive understanding of the gaps in the current market.
Analyze the GBM pipeline, stratified by stage of development, molecule type and molecular target.
Assess the therapeutic potential of first-in-class targets. Using a proprietary matrix, first-in-class products have been assessed and ranked according to clinical potential. Promising early-stage targets have been further reviewed in greater detail.
Identify commercial opportunities in the GBM deals landscape by analyzing trends in licensing and co-development deals.
Make an Enquiry of this report @ http://www.researchmoz.us/enquiry.php?type=E&repid=826604
Table of Contents
1 Table of Contents
1 Table of Contents 2
1.1 List of Tables 3
1.2 List of Figures 3
2 Executive Summary 4
2.1 Low Prevalence but a High Unmet Need and a Limited Number of Marketed Options 4
2.2 Moderately Sized but Innovative Pipeline 4
2.3 Moderately Active Deals Landscape, Mostly Involving Currently Established Targets 4
3 The Case for Innovation in the Glioblastoma Multiforme Market 5
3.1 Growing Opportunities for Biologic Products 5
3.2 Diversification of Molecular Targets 6
3.3 Innovative First-in-Class Product Developments Remain Attractive 6
3.4 Changes in Clinical and Commercial Environment to be More Favorable to Products Targeting Niche Patient Populations and Indications 6
3.5 Sustained Innovation 7
3.6 Report Guidance 7
4 Clinical and Commercial Landscape 8
4.1 Disease Overview 8
4.2 Epidemiology 8
4.3 Disease Symptoms 8
4.4 Etiology 9
4.4.1 Age, Rae and Gender 9
4.4.2 Genetic Factors 10
4.4.3 Environmental Factors 10
4.5 Pathophysiology 11
4.5.1 Tumor Initiation and Aberrant Cell Proliferation and Survival 11
4.5.2 Tumor Metabolic Shift 12
4.5.3 Tumor Progression, Micro-environment Alteration and Angiogenesis 12
4.5.4 Cancer Stem Cells 13
4.6 Diagnosis 14
4.7 GBM Prognosis and Prognostic Factors 15
4.8 Classification 15
4.8.1 Loss of Heterozygosity of Chromosome 10 16
4.8.2 Epidermal Growth Factor Receptor Amplification 17
4.8.3 Phosphatase and Tensin Homolog Mutation 17
4.8.4 Loss of p53 Function 17
4.8.5 p16INK4a Alteration and Loss of Normal Retinoblastoma 1 Function 17
4.8.6 Isocitrate Dehydrogenase 1 or Isocitrate Dehydrogenase 2 Mutation 18
4.9 Glioblastoma Multiforme Treatment 18
4.10 Surgery and Radiation Therapy 18
4.11 Overview of Marketed Products for Glioblastoma Multiforme 19
4.11.1 Chemotherapy 20
4.11.2 Targeted Therapies 21
4.12 Treatment Algorithm 21
4.13 Current Unmet Need in the GBM Market 23
5 Assessment of Pipeline Product Innovation 24
5.1 Glioblastoma Pipeline by Phase, Molecule Type and Molecular Target 24
5.2 First-in-Class Pipeline Programs 28
6 Signaling Network, Disease Causation and Innovation Alignment 33
6.1 The Complexity of Signaling Networks in Oncology 33
6.2 Signaling Pathways, Disease-Causing Mutations and First-in-Class Molecular Target Integration 34
6.3 First-in-Class Target Matrix Assessment 34
7 First-in-Class Target Evaluation 36
7.1 Pipeline Programs Targeting AKT 1 and 2 36
7.2 Pipeline Programs Targeting CDK1/2 37
7.3 Pipeline Programs Targeting PIK3CB and PIK3CG 38
7.4 Pipeline Programs which Target NTRK1 39
7.5 Pipeline Programs Targeting XIAP 41
7.6 Pipeline Programs Targeting Myc 42
7.7 Pipeline Programs Targeting PRKCA 43
7.8 Pipeline Programs which Target CASP8 and CASP9 44
7.9 Pipeline Programs which Target NR4A1 45
7.10 Pipeline Programs Targeting HIF-1? 45
7.11 Conclusion 47
8 Deals and Strategic Consolidations 48
8.1 Industry-Wide First-in-Class Deals 48
8.2 Glioblastoma Multiforme Deals Landscape 49
8.3 Licensing Deals 50
8.3.1 Molecule Type 52
8.3.2 Molecular Target 52
8.4 Co-development Deals 53
8.4.1 Molecule Type 55
8.4.2 Molecular Target 55
8.5 List of Pipeline Products without Prior Licensing or Co-Development Deal Involvement 57
9 Appendix 59
9.1 Abbreviations 59
9.2 References 60
9.3 Research Methodology 71
9.4 Secondary Research 71
9.4.1 Market Analysis 71
9.4.2 Pipeline Analysis 71
9.4.3 First-in-Class Matrix Assessment 72
9.4.4 First-in-Class Target Profiles 72
9.4.5 Licensing and Co-Development Deals 72
9.5 Contact Us 73
9.6 Disclaimer 73
ResearchMoz is the one stop online destination to find and buy market research reports & Industry Analysis. We fulfill all your research needs spanning across industry verticals with our huge collection of market research reports. We provide our services to all sizes of organizations and across all industry verticals and markets. Our Research Coordinators have in-depth knowledge of reports as well as publishers and will assist you in making an informed decision by giving you unbiased and deep insights on which reports will satisfy your needs at the best price.
90 State Street,
Albany NY - 12207
Website @ http://www.researchmoz.us/
Tel: 866-997-4948 (Us-Canada Toll Free)
Follow us on LinkedIn @ http://bit.ly/1TBmnVG
This release was published on openPR.
Permanent link to this press release:
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.
You can edit or delete your press release New Study on Frontier Pharma: Glioblastoma Multiforme - Cancer Immunotherapies Dominate First-in-Class Product Innovation here
News-ID: 369176 • Views: 297
More Releases from Researchmoz Global Pvt. Ltd.
Online Fitness Services Market Size, Share, Growth, Trend, Drivers and Restraint …
Online Fitness Services Market is predicted to grow at substantial compounded annual rate of growth (CAGR) during the forecast period 2020-2027. The markets growth is analysed by studying multiple determinants like Market Drivers, Trends, Challenges, Opportunities, Restraints, and Competition. It includes detailed analysis of the market on the basis of competitive profiles of key players, market segmentations, geographical analysis and economic models. The influence of Covid-19 on the market is discussed
Senior Living Market Current Status and Challenges with Future Opportunities to …
The Senior Living Market Report provides a detailed assessment of the market by highlighting information on various aspects including the global market, including drivers, restraints, opportunities, threats and development trends, competitive landscape analysis, and Growth status of key regions. The report provides comprehensive numerical analysis of the Senior Living industry and data for creating strategies to increase market growth and success. The report estimates market size, price, revenue, gross margin
Testing and Inspection Services Market 2020 Analysis includes Growth, Challenges …
The Testing and Inspection Services Market Report provides a detailed assessment of the market by highlighting information on various aspects including the global market, including drivers, restraints, opportunities, threats and development trends, competitive landscape analysis, and Growth status of key regions. The report provides comprehensive numerical analysis of the Testing and Inspection Services industry and data for creating strategies to increase market growth and success. The report estimates market size,
Proctoring Solution for Online Exams Market 2021 Leading Players, Industry Updat …
The study provides an in-depth study of the Proctoring Solution for Online Exams Market's trends and opportunities. On the basis of recent events and historical data, it makes figurative estimates and forecasts the future for the coming years. Moreover, the market document holds a substantial importance when it is about explaining market definition, classifications, applications and engagements. With the study of competitor analysis conducted in this Proctoring Solution for Online
More Releases for Target
Depression Cannot Hit A Moving Target
Cottonwood Heights, Utah, Mar 12, 2020 -- Depression can't hit a moving target. That was a phrase to live by for Chelsea Hansen. She was full of life and love, and she had big goals. But soon she was to discover that life doesn't turn out the way she planned. Behind the Fake Smile is a fictional book based on real-life experiences. It's the story of how Chelsea navigates a world
High Purity Aluminum Target Market
https://www.qandqmarketresearch.com/reports/7273640/high-purity-aluminum-target-market-80 The High Purity Aluminum Target market was valued at xx Million US$ in 2018 and is projected to reach xx Million US$ by 2025, at a CAGR of xx% during the forecast period. In this study, 2018 has been considered as the base year and 2019 to 2025 as the forecast period to estimate the market size for High Purity Aluminum Target. This report presents the worldwide High Purity Aluminum Target
Vaccines shine a spotlight over target infections
A vaccine is a biological formation that provides active acquired immunity to a particular disease. A vaccine typically contains an agent that features a disease-causing microorganism and is often made from weakened or killed forms of the micro-organism, its toxins, or one of its surface proteins. They create immunity against a disease. The traditional vaccine consists of agents that resemble the disease-causing organism. When these agents enter the human body
Chatbot : Opportunities to Reach better Target Audience
Chatbots is a computer program which conducts a discussion via auditory or documented methods. These programs are often designed to influentially simulate how a human would behave as a conversational partner, thereby passing the Turing test. Chatbots are basically used in dialog systems for various practical purposes including customer service or information acquisition. Some chatterbots use sophisticated natural language processing systems, but many simpler systems scan for keywords within the
BPOut stays on target
At the beginning of the year the BPOut announced the growth of the various teams, in Germany as well as internationally, as one of the most essential points of the strategy for 2014. A short look back at the first quarter confirms that the company stays on target due to several new projects with existing clients in addition to the increase of A350 electrics team. This fact indicates the trust that
BusinessVibes presents its Target Audience
London, UK, April 27, 2012 -- BusinessVibes is a global internet platform being included into a group of social media websites. In difference from Facebook or Twitter or other common known ones, BusinessVibes (http://www.businessvibes.com) is dedicated only to business, professional bodies. Main aim of the platform is to help them to look for new clients, suppliers and partners abroad. However, business entities and professionals are quite wide groups. Who is