Adrenal Crisis Market to Rise by 2034 | Eton Pharmaceuticals, Antares Pharma, and others expected to boost market

DelveInsight's "Adrenal Crisis Market Insights, Epidemiology, and Market Forecast-2034" report delivers an in-depth understanding of Adrenal Crisis, historical and forecasted epidemiology as well as the Adrenal Crisis market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

The Adrenal Crisis market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted Adrenal Crisis market size from 2020 to 2034, segmented by seven major markets. The Report also covers current Adrenal Crisis treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the Adrenal Crisis market.

Key highlights from the Adrenal Crisis Market Report:

The acquisition of Antares Pharma by Halozyme has put the future of ATRS-1902 in doubt, as there have been no recent updates on its development, although it still appears in the company's pipeline.
Growing awareness of this unique histology has facilitated the creation of drugs specifically targeting Adrenal Crisis, highlighting both commonalities and distinct characteristics. These developments, along with the anticipated arrival of new therapies, are expected to enhance the market's prospects.
In 2021, the Adrenal Crisis market in the seven major markets was valued at USD 11.5 million, with a total of 130,175 prevalent cases reported in those countries. Key players in the market include Eton Pharmaceuticals, Antares Pharma, and others focused on obesity-related treatments.

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Adrenal Crisis Overview

An adrenal crisis, also known as acute adrenal insufficiency, is a potentially life-threatening condition that occurs when the body experiences a severe lack of cortisol. This can happen due to various reasons, particularly in individuals with known adrenal insufficiency.
Causes
Primary Adrenal Insufficiency: Conditions like Addison's disease, where the adrenal glands are damaged.
Secondary Adrenal Insufficiency: Often due to abrupt withdrawal from long-term corticosteroid therapy or pituitary gland disorders that affect ACTH production.
Acute Stress: Illness, surgery, trauma, or infection can trigger a crisis in susceptible individuals.
Inadequate Steroid Replacement: Failure to increase steroid dosage during stress can lead to a crisis.
Waterhouse-Friderichsen Syndrome: Severe bacterial infections (like meningococcemia) leading to adrenal hemorrhage.
Signs and Symptoms
Severe Fatigue: Profound weakness and lethargy.
Nausea and Vomiting: Gastrointestinal distress is common.
Abdominal Pain: Often severe and can be mistaken for other conditions.
Hypotension: Low blood pressure, which can lead to shock.
Hypoglycemia: Low blood sugar levels can occur.
Confusion or Altered Mental Status: Cognitive changes due to low cortisol levels.
Electrolyte Imbalances: Hyperkalemia (high potassium) and hyponatremia (low sodium).
Diagnosis
Clinical Evaluation: History and physical examination focusing on symptoms.
Serum Cortisol Levels: Low levels, especially during a stress situation, indicate adrenal insufficiency.
ACTH Stimulation Test: Measures how well the adrenal glands respond to ACTH.
Electrolyte Panel: May show imbalances, particularly hyperkalemia and hyponatremia.
CT Scan or MRI: Imaging studies may be used to evaluate adrenal glands if indicated.
Treatment Options
Immediate Corticosteroid Administration: Intravenous hydrocortisone is the treatment of choice.
Fluid Resuscitation: IV fluids to manage dehydration and electrolyte imbalances.
Monitoring: Continuous monitoring of vital signs and laboratory values.
Addressing Underlying Causes: Treat any infections or other precipitating factors.
Long-term Management: Adjusting corticosteroid dosage based on stressors and individual needs.
Prevention
Education: Patients with adrenal insufficiency should be educated on recognizing early symptoms of a crisis.
Emergency Hydrocortisone Injections: Carrying an emergency supply for use in stress situations or illness.
Adjusting Medication During Stress: Increasing corticosteroid doses during illness, surgery, or other stressors, as advised by a healthcare provider.
An adrenal crisis is a medical emergency that requires prompt treatment to prevent serious complications or death. If you suspect someone is experiencing an adrenal crisis, seek emergency medical assistance immediately.

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Adrenal Crisis Market

Current treatment strategies for adrenal crisis primarily depend on established glucocorticoid replacement therapies such as hydrocortisone, prednisolone, and dexamethasone. These medications are essential for providing cortisol replacement, helping to mitigate the risk of adrenal crises and manage associated symptoms effectively. Additionally, mineralocorticoid replacement therapy, typically with fludrocortisone, may be used to restore electrolyte balance and regulate blood pressure, particularly in individuals with primary adrenal insufficiency.

Innovations in drug delivery systems are enhancing treatment efficacy and patient convenience. Long-acting formulations of glucocorticoids, including once-daily hydrocortisone and modified-release prednisolone tablets, offer improved pharmacokinetics and potentially better symptom control compared to traditional regimens. Emergency treatment protocols involve the immediate administration of parenteral hydrocortisone via bolus injection, followed by maintenance doses to stabilize the patient's condition. The industry standard for managing acute adrenal crises is Solu-Cortef Act-O-VIAL, a glucocorticoid designed for emergency use.

While traditional glucocorticoid therapies remain foundational, ongoing advancements in drug delivery, adjunctive therapies, and digital health solutions are shaping a more comprehensive, patient-centered approach to preventing and managing adrenal crises. These innovations reflect a commitment to enhancing the quality of life and long-term outcomes for individuals with adrenal insufficiency. Looking ahead, continued research and dedication bring optimism for more effective treatments and potentially a cure for this challenging condition, as indicated by projected market growth in the Adrenal Crisis sector in the coming years.

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Adrenal Crisis Epidemiology

Between 2019 and 2020, the prevalence of adrenal crisis was estimated to range from 5.2 to 8.3 per 100 patient-years. A postal survey of over 1,000 patients with primary adrenal insufficiency (PAI) indicated an annual frequency of adrenal crisis at 8%. It is estimated that patients diagnosed with adrenal insufficiency experience an adrenal crisis in approximately 6-8% of cases each year. Analysis of data from over 400 patients with adrenal insufficiency revealed a prevalence of 8 adrenal crises per 100 patient-years.

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Adrenal Crisis Marketed Drugs

SOLU-CORTEF: Pfizer Inc.

Adrenal Crisis Emerging Drugs

ATRS-1902: Antares Pharmaceuticals

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Adrenal Crisis Therapeutics Assessment

Major key companies such as Eton Pharmaceuticals, Antares Pharma, and others are working proactively in the Adrenal Crisis Therapeutics market to develop novel therapies which will drive the Adrenal Crisis treatment markets in the upcoming years.

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Adrenal Crisis Report Key Insights

1. Adrenal Crisis Patient Population
2. Adrenal Crisis Market Size and Trends
3. Key Cross Competition in the Adrenal Crisis Market
4. Adrenal Crisis Market Dynamics (Key Drivers and Barriers)
5. Adrenal Crisis Market Opportunities
6. Adrenal Crisis Therapeutic Approaches
7. Adrenal Crisis Pipeline Analysis
8. Adrenal Crisis Current Treatment Practices/Algorithm
9. Impact of Emerging Therapies on the Adrenal Crisis Market

Table of Contents

1. Key Insights
2. Executive Summary
3. Adrenal Crisis Competitive Intelligence Analysis
4. Adrenal Crisis Market Overview at a Glance
5. Adrenal Crisis Disease Background and Overview
6. Adrenal Crisis Patient Journey
7. Adrenal Crisis Epidemiology and Patient Population
8. Adrenal Crisis Treatment Algorithm, Current Treatment, and Medical Practices
9. Adrenal Crisis Unmet Needs
10. Key Endpoints of Adrenal Crisis Treatment
11. Adrenal Crisis Marketed Products
12. Adrenal Crisis Emerging Therapies
13. Adrenal Crisis Seven Major Market Analysis
14. Attribute Analysis
15. Adrenal Crisis Market Outlook (7 major markets)
16. Adrenal Crisis Access and Reimbursement Overview
17. KOL Views on the Adrenal Crisis Market
18. Adrenal Crisis Market Drivers
19. Adrenal Crisis Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer

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