Acute Kidney Injury Clinical Trials | A Drug Pipeline Analysis Report 2024 | GUARD THERAPEUTICS, Rénibus Therapeutics

DelveInsight's 'Acute Kidney Injury Pipeline Insight 2024' report provides comprehensive global coverage of available, marketed, and pipeline Acute Kidney Injury therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the Acute Kidney Injury pipeline domain.
Key Takeaways from the Acute Kidney Injury Pipeline Report
Over 30+ Acute Kidney Injury pipeline therapies are in various stages of development, and their anticipated acceptance in the Acute Kidney Injury market would significantly increase market revenue.
Leading Acute Kidney Injury companies developing novel drug candidates to improve the Acute Kidney Injury treatment landscape include GUARD THERAPEUTICS, Rénibus Therapeutics, and others.
Promising Acute Kidney Injury pipeline therapies in various stages of development include RMC-035, RBT-1, and others.
Request for a sample report @ https://www.delveinsight.com/report-store/acute-kidney-injury-aki-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Acute Kidney Injury Overview

Acute Kidney Injury (AKI) is a sudden and often severe decline in kidney function that occurs over a short period of time, typically within hours to days. It is characterized by a rapid increase in serum creatinine levels and/or a decrease in urine output. AKI can result from various causes and may range from mild to severe, potentially leading to serious complications if not managed promptly.

Causes of Acute Kidney Injury

AKI can be caused by a wide range of factors, which are generally classified into three categories based on the location of the injury:

1. Pre-Renal Causes: Conditions that lead to reduced blood flow to the kidneys, causing decreased kidney perfusion.
- Hypovolemia: Dehydration, bleeding, or fluid loss.
- Decreased Cardiac Output: Heart failure, myocardial infarction.
- Vascular Issues: Renal artery stenosis or thrombosis.

2. Intrinsic Renal Causes: Direct damage to the kidney tissues.
- Acute Tubular Necrosis (ATN): Often due to ischemia or nephrotoxins (e.g., certain medications, contrast dyes).
- Acute Glomerulonephritis: Inflammation of the glomeruli.
- Acute Interstitial Nephritis: Inflammation of the kidney interstitium, often due to allergic reactions to medications.

3. Post-Renal Causes: Obstructions in the urinary tract that impede urine flow from the kidneys.
- Urinary Tract Obstruction: Kidney stones, tumors, or an enlarged prostate.
- Bladder Outlet Obstruction: Difficulty in urine passing through the bladder.

Signs and Symptoms

Symptoms of AKI can vary depending on the underlying cause and severity of the condition. Common signs and symptoms include:

- Reduced Urine Output: Less frequent urination or very low urine volume.
- Swelling: Fluid retention causing swelling in the legs, ankles, or face.
- Fatigue: Feeling unusually tired or weak.
- Shortness of Breath: Due to fluid buildup in the lungs.
- Nausea and Vomiting: Gastrointestinal symptoms.
- Confusion: Changes in mental status or consciousness.
- High Blood Pressure: Elevated blood pressure.
- Itching: Skin itching due to accumulation of toxins.

Diagnosis

Diagnosing AKI involves a combination of clinical evaluation, laboratory tests, and imaging studies:

1. Clinical Evaluation:
- Medical History: Assessing risk factors, medications, and recent illnesses.
- Physical Examination: Checking for signs of fluid overload, swelling, and other symptoms.

2. Laboratory Tests:
- Serum Creatinine: Elevated levels indicate impaired kidney function.
- Blood Urea Nitrogen (BUN): Increased levels can also suggest kidney dysfunction.
- Electrolytes: Imbalances in sodium, potassium, and other electrolytes.
- Urinalysis: Detects abnormalities in urine composition, such as protein, blood, or casts.

3. Imaging Studies:
- Ultrasound: To assess kidney size, shape, and potential obstructions.
- CT Scan: Helps in identifying structural abnormalities, such as stones or tumors.
- MRI: Used in some cases for detailed imaging.

4. Additional Tests:
- Kidney Biopsy: May be performed if there is a need to determine the specific type of kidney injury.

Treatment Options

Treatment for AKI aims to address the underlying cause, support kidney function, and manage complications:

1. Pre-Renal AKI:
- Fluid Resuscitation: Administer intravenous fluids to restore blood volume and improve perfusion.
- Medications: Treat underlying conditions like heart failure or sepsis.

2. Intrinsic Renal AKI:
- Discontinue Nephrotoxins: Stop any medications or substances that may be causing damage.
- Treat Underlying Conditions: Manage conditions like glomerulonephritis or interstitial nephritis with appropriate medications.
- Supportive Care: Include monitoring and managing fluid and electrolyte balance.

3. Post-Renal AKI:
- Relieve Obstruction: Address the cause of the obstruction, such as removing kidney stones, treating an enlarged prostate, or placing a urinary catheter.

4. Supportive Care:
- Dialysis: In cases of severe AKI where kidney function is critically impaired, dialysis may be required to remove toxins and excess fluids.
- Nutritional Support: Dietary modifications to manage electrolyte and fluid balance.
- Monitoring and Follow-Up: Regular monitoring of kidney function and adjusting treatment as necessary.

Prognosis and Follow-Up

The prognosis of AKI depends on the cause, severity, and timeliness of treatment. With prompt and appropriate management, many individuals recover fully. However, some may experience long-term kidney damage or progress to chronic kidney disease. Regular follow-up is crucial to monitor kidney function and adjust treatment as needed.

Acute Kidney Injury is a serious condition that requires prompt diagnosis and intervention. Understanding its causes, symptoms, and treatment options is essential for effective management and improving patient outcomes.

To know more about Acute Kidney Injury pipeline segment, visit: https://www.delveinsight.com/report-store/acute-kidney-injury-aki-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Acute Kidney Injury Pipeline Analysis: Drug Profile
RMC-035: GUARD THERAPEUTICS
Guard Therapeutics is developing RMC-035 (ROSgard), a biological drug candidate that utilizes one of the body's most powerful and universal protections against oxidative stress. RMC-035 is naturally designed to "target" the kidneys, allowing RMC-035 to be present when the kidneys are attacked by oxidative stress. Treatment with RMC-035 has the potential to save lives and prevent the risk of both acute and chronic kidney damage with subsequent serious consequences due to impaired kidney function, such as life-sustaining dialysis treatment. Currently, it is in Phase II stage of clinical trial evaluation to treat Acute Kidney Injury.
Discover more about the emerging Acute Kidney Injury drugs @ https://www.delveinsight.com/sample-request/acute-kidney-injury-aki-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Acute Kidney Injury Key Companies
GUARD THERAPEUTICS
Rénibus Therapeutics
Acute Kidney Injury Pipeline Therapies
RMC-035
RBT-1
Acute Kidney Injury Pipeline Therapeutics Assessment
By development stage
By product type
By route of administration
By molecule type
By MOA type
Scope of the Acute Kidney Injury Pipeline Report
Coverage: Global
Key Acute Kidney Injury Companies: GUARD THERAPEUTICS, Rénibus Therapeutics, and others
Key Acute Kidney Injury Pipeline Therapies: GS 248, Treprostinil, and others
Find out more about the Acute Kidney Injury treatment options in development @ https://www.delveinsight.com/sample-request/acute-kidney-injury-aki-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Table of Contents
1. Introduction
2. Executive Summary
3. Overview
4. Pipeline Therapeutics
5. Late-Stage Products (Phase III)
6. Mid-Stage Products (Phase II)
7. Early Stage Products (Phase I/II)
8. Preclinical Stage Products
9. Discovery Stage Products
10. Therapeutic Assessment
11. Inactive Products
12. Collaborations Assessment- Licensing / Partnering / Funding
13. Unmet Needs
14. Market Drivers and Barriers
15. Appendix
16. About DelveInsight
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