Press release
Heart Failure Clinical Trials Assessment 2024: FDA Approvals, Pipeline, Therapies, MOA, ROA and Companies by DelveInsight | Abbott, Berlin Heart GmbH, Biotronik, Boston Scientific Corp, Jarvik Heart Inc., Lepu Medical, more
Heart Failure Clinical Trials
"Heart Failure Pipeline Insight, 2024" report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the Heart Failure Market.
The Heart Failure Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.
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Some of the key takeaways from the Heart Failure Pipeline Report:
• Heart Failure Companies across the globe are diligently working toward developing novel Heart Failure treatment therapies with a considerable amount of success over the years.
• Heart Failure companies working in the treatment market are Tenaya Therapeutics, Athersys, TransThera Biosciences, SalubrisBio, Ionis Pharmaceuticals, Arena Pharmaceuticals, Palatin Technologies, Bayer HealthCare, Eli Lilly and Company, and others, are developing therapies for the Heart Failure treatment
• Emerging Heart Failure therapies in the different phases of clinical trials are- TN-301, Invimestrocel, TT-00920, JK-07, IONIS AGT LRx, APD418, PL-3994, Finerenone, Tirzepatide, and others are expected to have a significant impact on the Heart Failure market in the coming years.
• In April 2024, The EMPACT-MI phase III clinical trial demonstrated a 10% relative risk reduction in the primary composite endpoint of time to first hospitalization due to heart failure or all-cause mortality for Jardiance® (empagliflozin) compared to placebo, though the results did not achieve statistical significance. Jardiance was administered to adults within 14 days of an acute myocardial infarction (heart attack) and showed a reassuring safety profile among this patient group.
• In January 2024, Bayer and its subsidiary Asklepios BioPharmaceutical (AskBio) have initiated the Phase II clinical trial for AB-1002, an investigational gene therapy aimed at treating congestive heart failure (CHF). This trial aims to evaluate the efficacy and safety of AB-1002 in adults diagnosed with non-ischemic cardiomyopathy, specifically those classified as NYHA Class III Heart Failure. Known as Gene PHosphatase Inhibition Therapy (GenePHIT), the study is a multicenter, double-blind, adaptive, placebo-controlled, randomized trial designed to assess the effects of a single intracoronary dose of AB-1002.
• In September 2023, Bayer has initiated three investigator-sponsored Phase III clinical trials to assess Kerendia (finerenone) for treating heart failure. Kerendia, a top-selling drug for Bayer, generated €67 million ($72.6 million) in sales in Q2 2023 according to the company's half-year report. GlobalData projects that sales could reach $1.4 billion by 2029.
Heart Failure Overview
Heart failure is a chronic condition in which the heart is unable to pump blood effectively to meet the body's needs. It can result from various underlying conditions, including coronary artery disease, high blood pressure, and diabetes. Heart failure is categorized into two main types: systolic heart failure, where the heart muscle is weakened and cannot contract forcefully enough, and diastolic heart failure, where the heart becomes stiff and cannot fill with blood properly. Heart failure Symptoms often include shortness of breath, fatigue, swelling in the legs and ankles, and persistent coughing or wheezing. Heart failure Diagnosis is typically based on medical history, physical examination, and tests such as echocardiograms, blood tests, and chest X-rays. Heart failure Treatment focuses on managing symptoms and underlying causes, including lifestyle changes, medications like ACE inhibitors, beta-blockers, and diuretics, and in some cases, surgical interventions such as heart transplants or the implantation of a pacemaker or defibrillator. Early detection and management are crucial for improving outcomes.
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Emerging Heart Failure Drugs Under Different Phases of Clinical Development Include:
• TN-301: Tenaya Therapeutics
• Invimestrocel: Athersys
• TT-00920: TransThera Biosciences
• JK-07: SalubrisBio
• IONIS AGT LRx: Ionis Pharmaceuticals
• APD418: Arena Pharmaceuticals
• PL-3994: Palatin Technologies
• Finerenone: Bayer HealthCare Pharmaceuticals
• Tirzepatide: Eli Lilly and Company
Heart Failure Route of Administration
Heart Failure pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as
• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical
Heart Failure Molecule Type
Heart Failure Products have been categorized under various Molecule types, such as
• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy
Heart Failure Pipeline Therapeutics Assessment
• Heart Failure Assessment by Product Type
• Heart Failure By Stage and Product Type
• Heart Failure Assessment by Route of Administration
• Heart Failure By Stage and Route of Administration
• Heart Failure Assessment by Molecule Type
• Heart Failure by Stage and Molecule Type
DelveInsight's Heart Failure Report covers around 90+ products under different phases of clinical development like
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I)
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration
Further Heart Failure product details are provided in the report. Download the Heart Failure pipeline report to learn more about the emerging Heart Failure therapies
https://www.delveinsight.com/sample-request/heart-failure-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr
Some of the key companies in the Heart Failure Therapeutics Market include:
Key companies developing therapies for Heart Failure are - Abbott Laboratories, Berlin Heart GmbH, Biotronik SE & Co. KG, Boston Scientific Corporation, Jarvik Heart Inc., Lepu Medical Technology (Beijing)Co.,Ltd., Magenta Medical Ltd, MEDICO S.R.L., Medtronic PLC, Oscor, Inc., OSYPKA MEDICAL, Shree Pacetronix Ltd, and others.
Heart Failure Pipeline Analysis:
The Heart Failure pipeline report provides insights into
• The report provides detailed insights about companies that are developing therapies for the treatment of Heart Failure with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Heart Failure Treatment.
• Heart Failure key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Heart Failure Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Heart Failure market.
The report is built using data and information traced from the researcher's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.
Download Sample PDF Report to know more about Heart Failure drugs and therapies
https://www.delveinsight.com/sample-request/heart-failure-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr
Heart Failure Pipeline Market Drivers
• Alongside these drug launches, a new therapeutic strategy is being explored, prevalence of chronic heart failure on the rise, strong collaboration between main stakeholders of therapeutic innovation: scientific community, industry and regulatory agencies are some of the important factors that are fueling the Heart Failure Market.
Heart Failure Pipeline Market Barriers
• However, true surrogate marker for mortality in heart failure (HF) remains elusive, high cost of approved therapies, transition of a clinical HFrEF project from one stage of development to the next is still associated with considerable development risk and other factors are creating obstacles in the Heart Failure Market growth.
Scope of Heart Failure Pipeline Drug Insight
• Coverage: Global
• Key Heart Failure Companies: Tenaya Therapeutics, Athersys, TransThera Biosciences, SalubrisBio, Ionis Pharmaceuticals, Arena Pharmaceuticals, Palatin Technologies, Bayer HealthCare, Eli Lilly and Company, and others
• Key Heart Failure Therapies: TN-301, Invimestrocel, TT-00920, JK-07, IONIS AGT LRx, APD418, PL-3994, Finerenone, Tirzepatide, and others
• Heart Failure Therapeutic Assessment: Heart Failure current marketed and Heart Failure emerging therapies
• Heart Failure Market Dynamics: Heart Failure market drivers and Heart Failure market barriers
Request for Sample PDF Report for Heart Failure Pipeline Assessment and clinical trials
https://www.delveinsight.com/sample-request/heart-failure-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr
Table of Contents
1. Heart Failure Report Introduction
2. Heart Failure Executive Summary
3. Heart Failure Overview
4. Heart Failure- Analytical Perspective In-depth Commercial Assessment
5. Heart Failure Pipeline Therapeutics
6. Heart Failure Late Stage Products (Phase II/III)
7. Heart Failure Mid Stage Products (Phase II)
8. Heart Failure Early Stage Products (Phase I)
9. Heart Failure Preclinical Stage Products
10. Heart Failure Therapeutics Assessment
11. Heart Failure Inactive Products
12. Company-University Collaborations (Licensing/Partnering) Analysis
13. Heart Failure Key Companies
14. Heart Failure Key Products
15. Heart Failure Unmet Needs
16 . Heart Failure Market Drivers and Barriers
17. Heart Failure Future Perspectives and Conclusion
18. Heart Failure Analyst Views
19. Appendix
20. About DelveInsight
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