Small lymphocytic lymphoma Pipeline, FDA Approvals, Unmet Needs, Preclinical and Discovery Stage Product, and Companies 2024 (Updated)

DelveInsight's, "Small Lymphocytic Lymphoma Pipeline Insight 2024" report provides comprehensive insights about 80+ companies and 80+ pipeline drugs in Small Lymphocytic Lymphoma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Key Takeaways from the Small lymphocytic lymphoma Pipeline Report

* DelveInsight's Small lymphocytic lymphoma pipeline report depicts a robust space with 80+ active players working to develop 80+ pipeline therapies for Small lymphocytic lymphoma treatment.
* The leading Small lymphocytic lymphoma Companies working in the market include Loxo Oncology, Iovance Biotherapeutics, Ascentage Pharma, NovalGen, Pfizer, and TG Therapeutics represent a diverse array of pharmaceutical companies, each contributing significantly to the advancements in healthcare. Chia Tai Tianqing Pharmaceutical Group, MingSight Pharmaceuticals, Jiangsu MingSight-Relin Pharmaceutical, and others.
* Promising Small lymphocytic lymphoma Therapies in the various stages of development include ofatumumab, Ibrutinib, Obinutuzumab, Chlorambucil, Arzerra, FC infusion, and others.
* May 2024:- Juno Therapeutics, a Subsidiary of Celgene- An Open-Label, Phase 1/2 Study of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (017004). This is a Phase 1/2, open-label, multicenter study to determine the efficacy and safety of JCAR017 in adult subjects with relapsed or refractory CLL or SLL. The study will include a Phase 1 part to determine the recommended dose of JCAR017 monotherapy in subjects with relapsed or refractory CLL or SLL, followed by a Phase 2 part to further assess the efficacy and safety of JCAR017 monotherapy treatment at the recommended dose.
* May 2024:- Merck Sharp & Dohme LLC- A Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Nemtabrutinib (MK-1026) Plus Venetoclax Versus Venetoclax Plus Rituximab in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Following at Least 1 Prior Therapy (BELLWAVE-010).
* May 2024:- Inhye Ahn- A Phase 2 Study of Fixed Duration Therapy With Pirtobrutinib and Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia (POP). This study will evaluate fixed-duration therapy with pirtobrutinib and obinutuzumab given over 12 cycles (approximately 1 year) as first-line treatment of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL or SLL).

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Small lymphocytic lymphoma Overview

SLL is an indolent (slow growing) non-Hodgkin lymphoma that affects B cells. B cells (also known as B lymphocytes) are specialized white blood cells. Under normal conditions they produce immunoglobulins (also called antibodies) that help protect our bodies against infection and disease. Small lymphocytic lymphoma is considered part of the same disease process as CLL; however, the disease is known as SLL when it involves a lymph node, and CLL when it involves the peripheral blood.

Small lymphocytic lymphoma treatment may involve the use of low or high intensity combination chemotherapy, more recently with a targeted therapy such as a monoclonal antibody. This is commonly known as chemo immunotherapy. The combination of drugs will depend on age, stage of disease and risk factors. Small lymphocytic lymphoma that accumulates in the bone marrow and the spleen can deplete the amount of healthy blood cells in the circulating blood (blood that flows throughout the body).

Small lymphocytic lymphoma Emerging Drugs Profile

* TQ-B3525: Chia Tai Tianqing Pharmaceutical Group

TQ-B3525 is a novel and selective oral PI3K / inhibitor with activity 41 and 138 folds higher than Buparlisib against PI3K and PI3K in pre-clinical research. TQ-B3525 is well-tolerated in Chinese patients with advanced malignancies, and demonstrated high promising antitumor activity in R/R lymphoma patients.Currently,the drug is in Phase I/II stage of Clinical trial evaluation for the treatment of SLL.

* LOXO-305: Loxo Oncology

Pirtobrutinib (LOXO-305), is an investigational, oral, highly-selective non-covalent Bruton's tyrosine kinase (BTK) inhibitor. BTK plays a key role in the B-cell antigen receptor signaling pathway, which is required for the development, activation and survival of normal white blood cells, known as B-cells, and malignant B-cells. BTK is a validated molecular target found across numerous B-cell leukemias and lymphomas including chronic lymphocytic leukemia, mantle cell lymphoma, Waldenstrom's macroglobulinemia, and marginal zone lymphoma.

* IOV 2001: Iovance Biotherapeutics

IOV 2001 is an adoptive cell therapy consist of autologous peripheral blood lymphocytes (PBL) being developed by Iovance Biotherapeutics. Currently, the drug is in Phase I/II stage of Clinical trial evaluation for the treatment of SLL.

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Small lymphocytic lymphoma Therapeutics Assessment

There are approx. 80+ key companies which are developing the therapies for Small Lymphocytic Lymphoma. The companies which have their Small Lymphocytic Lymphoma drug candidates in the most advanced stage, i.e. phase III include, Loxo Oncology.

DelveInsight's Small lymphocytic lymphoma pipeline report covers around 80+ products under different phases of clinical development like

* Late stage products (Phase III)
* Mid-stage products (Phase II)
* Early-stage product (Phase I) along with the details of
* Pre-clinical and Discovery stage candidates
* Discontinued & Inactive candidates

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Small lymphocytic lymphoma Companies

Loxo Oncology, Iovance Biotherapeutics, Ascentage Pharma, NovalGen, Pfizer, and TG Therapeutics represent a diverse array of pharmaceutical companies, each contributing significantly to the advancements in healthcare. Chia Tai Tianqing Pharmaceutical Group, MingSight Pharmaceuticals, Jiangsu MingSight-Relin Pharmaceutical, and others.

Small Lymphocytic Lymphoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration

* Intra-articular
* Intraocular
* Intrathecal
* Intravenous
* Ophthalmic
* Oral
* Parenteral
* Subcutaneous
* Topical
* Transdermal

Small lymphocytic lymphoma Products have been categorized under various Molecule types such as

* Oligonucleotide
* Peptide
* Small molecule

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Scope of the Small lymphocytic lymphoma Pipeline Report

* Coverage- Global
* Small lymphocytic lymphoma Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
* Small lymphocytic lymphoma Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
* Small lymphocytic lymphoma Companies- Loxo Oncology, Iovance Biotherapeutics, Ascentage Pharma, NovalGen, Pfizer, and TG Therapeutics represent a diverse array of pharmaceutical companies, each contributing significantly to the advancements in healthcare. Chia Tai Tianqing Pharmaceutical Group, MingSight Pharmaceuticals, Jiangsu MingSight-Relin Pharmaceutical, and others.
* Small Lymphocytic Lymphoma Therapies- ofatumumab, Ibrutinib, Obinutuzumab, Chlorambucil, Arzerra, FC infusion, and others.

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Table of Content

* Introduction
* Executive Summary
* Small Lymphocytic Lymphoma: Overview
* Pipeline Therapeutics
* Therapeutic Assessment
* Small Lymphocytic Lymphoma- DelveInsight's Analytical Perspective
* Late Stage Products (Pre-Registration)
* Drug Name : Company Name
* Drug profiles in the detailed report.....
* Last Stage Products (Phase III)
* LOXO-305: Loxo Oncology
* Drug profiles in the detailed report.....
* Mid Stage Products (Phase I/II)
* TQ-B3525: Chia Tai Tianqing Pharmaceutical Group
* Drug profiles in the detailed report.....
* Preclinical and Discovery Stage Products
* Drug name : Company name
* Drug profiles in the detailed report.....
* Inactive Products
* Small Lymphocytic Lymphoma Key Companies
* Small Lymphocytic Lymphoma Key Products
* Small Lymphocytic Lymphoma - Unmet Needs
* Small Lymphocytic Lymphoma - Market Drivers and Barriers
* Small Lymphocytic Lymphoma - Future Perspectives and Conclusion
* Small Lymphocytic Lymphoma Analyst Views
* Small Lymphocytic Lymphoma Key Companies
* Appendix

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