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Downstream Processing Market Size Worth USD 121.51 Billion in 2032 | Emergen Research
The DownStream Processing Market size was USD 31.04 Billion in 2022 and is expected to register a rapid revenue CAGR of 15.0% during the forecast period. The global downstream processing market is experiencing significant growth driven by rising investments in Research & Development (R&D) and technological advancements, according to a recent market research report. The report highlights key factors contributing to market expansion and identifies emerging trends shaping the industry landscape.Key Market Drivers
The rapid growth of the biopharmaceutical industry stands out as a primary driver of downstream processing market revenue. Biopharmaceuticals, including monoclonal antibodies, recombinant proteins, and gene therapies, offer targeted treatments for various diseases, fueling demand for downstream processing methods. These methods ensure large-scale production of high-purity biopharmaceuticals, addressing the growing need for effective therapies.
Continuous innovation in biopharmaceutical R&D leads to the development of novel molecule types, requiring adapted downstream processing techniques for isolation and purification. Moreover, efforts are underway to create newer and more efficient processing technologies such as continuous chromatography and single-use systems, enhancing yield and reducing costs. Sustainability is also a focus, with initiatives exploring greener processes and automation integration.
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Technological Advancements
The introduction of Ultra-Scale-Down (USD) Bioprocessing marks a significant advancement, allowing rapid experimentation at reduced volumes, cutting material costs, and accelerating process development. Additionally, the integration of Artificial Intelligence (AI) and Advanced Spectroscopy and Analytics is transforming downstream processing, enhancing efficiency and quality.
Market Restraints and Segment Insights
Workforce challenges pose a significant restraint, with a gap between required skills and available talent leading to operational inefficiencies. However, market segments such as chromatography columns and filters continue to dominate, driven by cost-effectiveness and reliability. The purification segment, targeting high-purity biopharmaceuticals, is expected to maintain significant market share, while solid-liquid separation techniques see moderate growth.
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Application and End-Use Segments
In terms of application, antibiotics and monoclonal antibodies lead the market, driven by rising demand for effective treatments. Biopharmaceutical manufacturers constitute the largest end-use segment, handling downstream processing internally or outsourcing to specialized Contract Manufacturing Organizations (CMOs).
Collaborative Initiatives
Collaborations between industry leaders, such as Merck and Agilent Technologies, are pushing the boundaries of Process Analytical Technologies (PAT), enhancing downstream process monitoring and control. These partnerships leverage expertise in bioprocesses and analytical solutions to optimize critical process parameters and quality attributes.
Outlook
With ongoing technological advancements and the expansion of the biopharmaceutical industry, the downstream processing market is poised for continued growth. Efforts to address workforce challenges and navigate regulatory requirements will be crucial for sustained market expansion.
Downstream Processing Top Companies and Competitive Landscape
The global downstream processing market is fairly fragmented with many large and medium-sized players accounting for majority of market revenue. Major players are deploying various strategies, entering into mergers & acquisitions, strategic agreements & contracts, developing, testing, and introducing more effective downstream processing solutions.
• Thermo Fisher Scientific Inc.
• Sartorius AG
• 3M
• Boehringer Ingelheim International GmbH
• Lonza
• Eppendorf SE
• Corning Incorporated
• Asahi Kasei Corporation.
• GE HealthCare
• Fenner Group Holdings Limited
Downstream Processing Latest Industry News
• On 5 June 2023, Waters and Sartorius announced its partnership to streamline downstream biomanufacturing. This means integrating software and hardware between Waters' PATROL UPLC system and Sartorius' Resolute BioSMB platform. This delivers immediate, on-site analytics, transforming how bioengineers see downstream processing.
• On 5 January 2023 Sartorius and RoosterBio announced their partnership to increase exosome production and purity. Sartorius brought their expertise in bioreactors, analytical tools, and purification solutions to create efficient yet gentle exosome isolation methods. Sartorius brought their expertise in bioreactors, analytical tools, and purification solutions to create efficient yet gentle exosome isolation methods. RoosterBio's hMSC banks, specialized growth and production media further improve scalability and yield. Both companies collaborate on analytical techniques to guarantee the purity and potency of the final exosome product.
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Downstream Processing Market Segment Analysis
For the purpose of this report, Emergen Research has segmented the global downstream processing market on the basis of technique, product, application, end-use, and region:
• Technique Outlook (Revenue, USD Billion; 2019-2032)
o Purification
o Formulation
o Clarification
o Cell Disruption
o Solid-liquid Separation
• Product Outlook (Revenue, USD Billion; 2019-2032)
o Chromatography Columns
o Resins
o Filters
• Application Outlook (Revenue, USD Billion; 2019-2032)
o Antibiotic Production
o Hormone Production
o Antibodies Production
o Vaccine Production
o Others
• End-Use Outlook (Revenue, USD Billion; 2019-2032)
o Biopharmaceutical Manufacturers
o Contract Manufacturing Services
o Others
• Regional Outlook (Revenue, USD Billion; 2019-2032)
o North America
1. U.S.
2. Canada
o Europe
1. Germany
2. France
3. UK
4. Italy
5. Spain
6. Benelux
7. Russia
8. Rest of Europe
o Asia Pacific
1. China
2. Japan
3. South Korea
4. India
5. ASEAN Countries
6. Oceania
7. Rest of APAC
o Latin America
1. Brazil
2. Mexico
3. Rest of LATAM
o Middle East & Africa
1. GCC Countries
2. Israel
3. Turkey
4. South Africa
5. Rest of Middle East & Africa
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