Press release
RNA Based Therapeutic Market Trends 2023: Expected to Grow at a CAGR of 17.6% by 2030 | Biogen, Gradalis, Silence Therapeutics
Competitive Landscape:
Silence Therapeutics plc.
Arbutus Biopharma Corporation
Ionis Pharmaceuticals
Sarepta Therapeutics
Alnylam Pharmaceuticals, Inc.
Benitec Biopharma Inc.
Genzyme (Sanofi), Arrowhead Pharmaceuticals
Biogen, Inc.
Gradalis, Inc.
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Gene Silencing: RNA-based therapeutics are being used for gene silencing to treat various diseases. Small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs) are designed to target specific RNA molecules and inhibit their expression, providing potential treatments for conditions like genetic disorders, cancers, and viral infections.
RNA Interference (RNAi): RNAi is a biological process that regulates gene expression by silencing target genes through the degradation of specific RNA molecules. This mechanism has been harnessed to develop RNA-based therapeutics that can selectively inhibit disease-causing genes, showing promise in treating genetic disorders and certain types of cancers.
Market Segmentation:
Therapeutic Modality:
a. mRNA Therapeutics: This segment includes mRNA-based therapies, such as mRNA vaccines, which encode specific proteins to elicit an immune response or deliver therapeutic molecules.
b. RNA Interference (RNAi): This segment encompasses RNAi-based therapeutics that utilize small interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs) to silence or knockdown specific disease-causing genes.
c. Antisense Oligonucleotides (ASOs): ASOs are synthetic RNA molecules designed to bind to specific RNA targets and modulate gene expression, either by blocking translation or promoting degradation.
d. Others: This segment includes other RNA-based therapeutic modalities, such as aptamers or ribozymes, which have unique mechanisms of action.
Indication:
a. Infectious Diseases: This segment includes RNA-based therapeutics targeting viral or bacterial infections, such as mRNA vaccines for COVID-19 or RNA-based antiviral therapies.
b. Genetic Disorders: RNA-based therapeutics can target specific genetic mutations responsible for inherited diseases, including rare genetic disorders.
c. Cancer: RNA-based therapeutics are being developed to selectively target cancer cells or inhibit specific oncogenes, potentially offering personalized treatment options.
d. Neurological Disorders: This segment focuses on RNA-based therapies for neurological conditions like Alzheimer's disease, Parkinson's disease, or amyotrophic lateral sclerosis (ALS).
e. Cardiovascular Disorders: RNA-based therapeutics targeting cardiovascular diseases, such as atherosclerosis or heart failure, fall under this segment.
End User:
a. Hospitals and Clinics: RNA-based therapeutics may be administered in hospital or clinical settings, particularly for acute conditions or advanced therapies.
b. Research Institutes: Academic and research institutions play a crucial role in developing and studying RNA-based therapeutics.
c. Pharmaceutical and Biotechnology Companies: This segment includes companies involved in the research, development, and commercialization of RNA-based therapies.
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