Downstream Processing Market Size, Share & Trends Analysis Report, 2030

The global downstream processing market size is expected to reach USD 94.79 billion by 2030, according to a new report by Grand View Research, Inc. The market is expected to expand at a CAGR of 14.84% from 2023 to 2030. The capacity requirements during the development of biologic drugs have changed over the past few years, wherein the demand for manufacturing high-volume products has shifted to developing small-volume, high-potency products. This creates new avenues for single-use technologies. A rise in the utilization of downstream processing techniques for the development of COVID-19 vaccines is a significant factor driving the market. The adoption of small-scale, single-use systems for process development and downstream processing is already high.

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Thus, evolutionary changes are expected in the area of single-use technologies for manufacturing small-volume, highly-potent drugs. The development of novel film chemistries, closed systems, automation in clinical-scale single-use systems, and smart sensors are some noteworthy advancements in the field. A rise in applications of downstream processing for the production of biopharmaceuticals is expected to bring growth opportunities to the market. This has also led to an increase in strategic deals and development in the market. For instance, in February 2021, Evozyne, LLC collaborated with a leading rare disorders drug manufacturer for the production and marketing of novel biopharmaceuticals for immune modulation.

Key players are investing in the bioprocessing of vaccines and therapies for COVID-19 to increase their market share. For instance, in May 2022, Lonza and ALSA Ventures are partnering to provide biotech firms with development and manufacturing services. In May 2022, Lonza added Titanium Dioxide-free white hard gelatin capsules to its Capsugel Capsule Line. The new capsule includes an alternative opacifying technology that provides a good masking solution as well as enhanced light protection for the fill formulation. In December 2021, Repligen bought Newton, New Jersey-based BioFlex Solutions. The purchase adds to and enhances Repligen's single-use fluid management product line, as well as simplifies its supply chain. The integration of BioFlex Solutions strengthens its system offering by further integrating components and assemblies.

Downstream Processing Market Report Highlights

• The chromatography systems segment dominated the market for downstream processing and accounted for the largest revenue share of 41.29% in 2022
• The advent of single-use chromatography systems that bring an 80.0% reduction of the use of water and chemicals for buffer has further increased the adoption of chromatography for downstream processing of bio-therapeutics
• Filters are anticipated to grow at a lucrative rate over the forecast period. Efforts undertaken by the key players to develop intelligent membranes for purification & separation is fuelling the market growth
• Purification by chromatography accounted for the largest revenue share as it can be employed across all steps of a downstream process. The technique is also crucial in bioprocessing to obtain pure biologics
• The antibiotic production segment dominated the market for downstream processing and generated the largest revenue share of 32.48% in 2022 owing to the wide applications of antibiotics for the treatment of several disorders.
• A rise in occurrences of antibiotic resistance also propels the industrial-scale development of novel antibiotic candidates
• North America dominated the market for downstream processing with the largest revenue share of 34.57% in 2022 owing to government support for promoting bioprocess technologies, rising medical expenditure, and developed healthcare infrastructure.
• Asia Pacific expected to register the highest growth rate of 15.67% during 2023-2030 due to a rise in contract development services in emerging economies

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Downstream Processing Market Segmentation
Grand View Research has segmented the global downstream processing market based on product, technique, application, and region:

Downstream Processing Product Outlook (Revenue, USD Billion, 2018 - 2030)
• Chromatography Systems
• Filters
• Evaporators
• Centrifuges
• Dryers
• Others

Downstream Processing Technique Outlook (Revenue, USD Billion, 2018 - 2030)
• Cell Disruption
• Solid-liquid separation
o Filtration
o Centrifugation
• Concentration
o Evaporation
o Membrane filtration
• Purification by Chromatography
• Formulation

Downstream Processing Application Outlook (Revenue, USD Billion, 2018 - 2030)
• Antibiotic Production
• Hormone Production
• Antibodies Production
• Enzyme Production
• Vaccine Production

Regional Insights
North America dominated the market for downstream processing with the largest revenue share of 34.57% in 2022 owing to government support for promoting bioprocess technologies, rising medical expenditure, and developing healthcare infrastructure. In addition, the region has witnessed major collaborative activities with healthcare giants that are extensively investing in the R&D of biopharmaceuticals and vaccines. In addition, key players operating in the market for downstream processing are expanding their foothold in this region. For instance, Thermo Fisher Scientific Inc. recently announced a USD 97 million investment to extend its clinical research facilities in Richmond, Virginia. The facilities, which comprise laboratory operations obtained with the acquisition of PPD, Inc. in December 2021, will meet the growing need for consistent, greater laboratory services in biopharma to advance drug development.

In the Asia Pacific, the market for downstream processing is expected to register the highest growth rate of 15.67% during 2023-2030 due to the rising investments by developers and consumers in the field of biotechnology. The presence of a large population base is driving the need for advanced medical facilities for which players are keen on implementing rapid analytical methods to support in-process designing and bioprocessing. China dominated the market share in the Asia Pacific owing to the growing biopharmaceutical industry and increasing demand for medicines and vaccines.
The biopharmaceutical industry is amongst the most active economic sectors in China and is marked by continuous revolution with modern biopharmaceutical equipment and process. For instance, in April 2021, Asahi Kasei Corporation, a solution supplier to the biologics manufacturing sector, extended its operations in China with the establishment of Asahi Kasei Bioprocess Co., Ltd. By localizing inventory management and order processing for faster delivery periods, the introduction of AKBC facilitates company development in China.

List of Key Players in the Downstream Processing Market
• Merck KGaA
• Sartorius Stedim Biotech S.A
• GE Healthcare
• Thermo Fisher Scientific Inc.
• Danaher Corporation
• Repligen
• 3M Company
• Boehringer Ingelheim International GmbH
• Corning Corporation
• Lonza Group Ltd
• Dover Corporation
• Ashai Kasei
• Ferner PLC
• Eppendorf AG

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This release was published on openPR.