Cytokine Release Syndrome Market in 7MM is expected to witness a major change in the study period 2019-2032 | Major Companies- Genentech, Novartis Pharmaceuticals, and Others

"The upsurge in the Cytokine Release Syndrome Market is a direct consequence of higher usage of CAR-T cell therapies in Hematological cancer patients across 7MM. Increase in Cytokine Release Syndrome Market Size anticipated for the study period, 2019-2032"

The Cytokine Release Syndrome market report provides current treatment practices, emerging drugs, Cytokine Release Syndrome market share of the individual therapies, current and forecasted Cytokine Release Syndrome market Size from 2019 to 2032 segmented by seven major markets. The Report also covers current Cytokine Release Syndrome treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the Cytokine Release Syndrome market.

Key takeaways from the Cytokine Release Syndrome Market Report
• Cytokine Release Syndrome Market is expected to show positive growth, during the study period of 2019 to 2032, DelveInsight
• Total number of patients who develop Cytokine Release Syndrome following CAR-T Therapies in the 7MM were 3,720 in 2021.
• Total number of patients who develop Cytokine Release Syndrome following Bispecific Antibody Therapies in the 7MM were 398 in 2021.
• Cytokine Release Syndrome Market Companies included Genentech, Novartis Pharmaceuticals, Incyte Corporation, CytoSorbents, Jazz pharmaceuticals, Swedish Orphan Biovitrum (Sobi), and several others
• Cytokine Release Syndrome Market Therapies included Actemra/RoActemra (tocilizumab), Canakinumab (Ilaris), Itacitinib, Cytosorb, Defitelio (Defibrotide), Anakinra, and several others

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Cytokine Release Syndrome Overview
Cytokine Release Syndrome is an acute systemic inflammatory response characterized by fever and multiple organ dysfunction associated with CAR T-cell therapy, therapeutic antibodies, and haploidentical allogeneic transplantation etc. Immune effector cell-associated neurotoxicity syndrome (ICANS) is a neuropsychiatric syndrome that can occur in some patients treated with immunotherapy and may or may not accompany CRS.
Cytokine Release Syndrome complex signs and symptoms result from the effects of cytokines released by the CAR T cells once engaged with the target. Serum levels of inflammatory cytokines are elevated, particularly IL‐6. The severity of symptoms may correlate with the serum cytokine concentrations and the duration of exposure to the inflammatory cytokines.

Cytokine Release Syndrome Epidemiology Insights
In the DelveInsight's epidemiology model, we have taken total incidence cases of B-cell NHL, ALL and MM, out of which we have excluded those patients who received first-line treatment. While remaining patients referred as relapsed/refractory cases of B-cell NHL, ALL and MM. In the second-line treatment, few patients were eligible to receive CAR-T cells. Furthermore, we have taken all those CAR-T therapies that are approved or in development for the B-cell NHL, ALL, and MM.

Cytokine Release Syndrome Epidemiology Segmentation in the 7MM
• Cytokine Release Syndrome Treated Cases
• Cytokine Release Syndrome by CAR-T Therapies
• Cytokine Release Syndrome Grade-specific Cases
• Cytokine Release Syndrome Cases by Allogenic Transplant

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Cytokine Release Syndrome Treatment Landscape
Antigen-specific immunotherapies have immense potential to harness and fortify the inherent antitumor capacity of the immune system. Due to their unparalleled success in recent years, antigen-targeting immunotherapies such as chimeric antigen receptor (CAR) T-cells and bi-specific T-cell engagers (BiTEs) have become state-of-the-art approaches for treating hematological malignancies. Although a significant portion of the innovation and engineering has been invested toward improving the efficacy and potency of these T-cell-engaging immunotherapies, these therapeutic strategies are prone to vary degrees of toxicities, including cytokine release syndrome (CRS) and neurotoxicity syndrome.

Cytokine Release Syndrome Market Insights
The Cytokine Release Syndrome is among the most frequent serious adverse events and represents a major cause of morbidity following T-cell-engaging immunotherapy. Insights gained from studying the biological mechanisms of Cytokine Release Syndrome and the clinical use of corticosteroids and IL-6 blockade have already improved the management of patients with Cytokine Release Syndrome. However, there remain many unanswered questions, and there is still ample room for improvement for the clinical management of Cytokine Release Syndrome.

Cytokine Release Syndrome Emerging Therapies
• Corticosteroids
• ACTEMRA (tocilizumab): Roche
• Itacitinib: Incyte Corporation
• KINERET (anakinra): Swedish Orphan Biovitrium (SOBI)

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Scope of the Cytokine Release Syndrome Market Report
• Study Period- 2019-2032
• Forecast Period- 11 years
• Cytokine Release Syndrome Market Companies included Genentech, Novartis Pharmaceuticals, Incyte Corporation, CytoSorbents, Jazz pharmaceuticals, Swedish Orphan Biovitrum (Sobi), and several others
• Cytokine Release Syndrome Market Therapies included Actemra/RoActemra (tocilizumab), Canakinumab (Ilaris), Itacitinib, Cytosorb, Defitelio (Defibrotide), Anakinra, and several others
• Cytokine Release Syndrome Market Dynamics: Cytokine Release Syndrome Market Drivers and Barriers

Table of content
1. Key Insights
2. Cytokine Release Syndrome Executive Summary
3. Competitive Intelligence Analysis for Cytokine Release Syndrome
4. Cytokine Release Syndrome: Market Overview at a Glance
5. Cytokine Release Syndrome: Disease Background and Overview
6. Patient Journey
7. Cytokine Release Syndrome Epidemiology and Patient Population
8. Treatment Algorithm, Current Treatment, and Medical Practices
9. Cytokine Release Syndrome Unmet Needs
10. Key Endpoints of Cytokine Release Syndrome Treatment
11. Cytokine Release Syndrome Marketed Products
12. Cytokine Release Syndrome Emerging Therapies
13. Cytokine Release Syndrome: Seven Major Market Analysis
14. Attribute analysis
15. 7MM: Cytokine Release Syndrome Market Outlook
16. Access and Reimbursement Overview of Cytokine Release Syndrome
17. Cytokine Release Syndrome KOL Views
18. Cytokine Release Syndrome Market Drivers
19. Cytokine Release Syndrome Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
23. About DelveInsight

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