Gaucher's Disease Market in 7MM is expected to witness a major change in the study period 2019-2032 | Major Companies- Genzyme, Sanofi, and Others

DelveInsight's "Gaucher's Disease Market" report provides a thorough comprehension of the Gaucher's Disease, historical and forecasted epidemiology, and the Gaucher's Disease market trends in the 7MM [the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan]. The Gaucher's Disease market report also proffers an analysis of recent Gaucher's Disease treatment algorithm/practice, market drivers, market barriers, and unmet medical needs.

The Gaucher's Disease market is expected to show positive growth, mainly attributed to the increased diagnosed prevalence and also, the launch of upcoming devices during the forecast period. Moreover, advances in disease mechanisms have yielded new diagnostic and treatment approaches, opening avenues to better treatment interventions.

Key takeaways from Gaucher's Disease Market Report
• The Gaucher's Disease market is expected to grow due to an increase in diabetes cases, expected entry of emerging therapies, and readily adoption of these novel therapies.
• According to Nalsnyk et al. (2016), the standardized birth incidence of GD in the general population varied from 0.39 to 5.80 per 100 000, and prevalence ranged from 0.70 to 1.75 per 100 000, respectively.
• According to Jun et al. (2022), females born with GD does not have any family history whereas male child born with GD have family history.
• According to NORD, there are approximately 6,000 individuals with GD in the United States. Gaucher's Disease is the most common genetic disorder of persons of Ashkenazic Jewish ancestry, where the incidence may be as high as 1 in 450 births. There is no ethnic prevalence associated with Gaucher's Disease types 2 or 3.
• Gaucher's Disease Market Companies included Genzyme, Sanofi, Takeda (Shire), and several others.
• Gaucher's Disease Market Drugs included Cerezyme, Eliglustat, Velaglucerase alfa, and several others.

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Gaucher's Disease Overview

Gaucher's Disease is an inherited metabolic disorder, caused due to deficiency of an enzyme called glucocerebrosidase (GCase). Enzymes like GCase are proteins that perform several tasks, including breaking down fats (sphingolipids) in the body. This deficiency cause's buildup of fatty chemicals (called gaucher cells) in the organs, bone marrow and brain. The excess fats cause of a wide range of problems and symptoms. They affect how the organs work, and they destroy blood cells and weaken bones.

Gaucher's Disease Epidemiology Insights

Gaucher's Disease is an inherited metabolic disorder. People with Gaucher's Disease don't have enough of an enzyme called glucocerebrosidase (GCase). Enzymes like GCase are proteins that perform several tasks, including breaking down fats (sphingolipids) in the body. If the body doesn't have enough of these enzymes, fatty chemicals (called Gaucher cells) build up in the organs, bone marrow and brain. The excess fats cause a wide range of problems and symptoms. They affect how the organs work, and they destroy blood cells and weaken bones.

Gaucher's Disease Epidemiology Segmentation in the 7MM
• Total Gaucher's Disease Prevalent Cases
• Gaucher's Disease Subtype-specific Prevalent Cases
• Gaucher's Disease Diagnosed and Treatable Cases

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Gaucher's Disease Treatment Market

Gaucher's Disease treatment options include various pain reduction therapies, blood transfusions, orthopedic surgery for bone and joints, and rare splenectomy. Gaucher's Disease treatment is tailored to the individual patient because of the variability in the manifestations, severity, and progression of the disease. Treatment of Gaucher's Disease aims at reducing the symptoms and preventing permanent damage to the body. Enzyme Replacement Therapy (ERT) and Substrate Reduction Therapy (SRT) are the mainstay therapies used for improving the symptoms, prevention of irreversible complications such as massive fibrous splenomegaly secondary osteoarthritis, vertebral compression, and other fractures, hepatic fibrosis and lung fibrosis, and improving overall health and quality of life of patients with Gaucher Disease. Various pain reduction therapies, blood transfusions, orthopedic surgery are used for the management of the signs and symptoms of Gaucher Disease.

Gaucher's Disease Market Landscape

Growing awareness about Gaucher's Disease and its treatment options, increasing R&D expenditures leading to high pipeline products, and increase in prevalence of Gaucher's Diseases along with high unmet needs are the major factors that are supporting the growth of the Gaucher's Disease therapeutics market globally. The growth of the segment can be attributed to the strong sales of Cerezyme and Vpriv. However, there has been an increase in inclination towards substrate replacement therapy (SRT), spearheaded by Cerdelga and Zavesca. ERT is mostly indicated for type 1 and type 3 (to address issues unrelated to the CNS), as replacement enzymes cannot penetrate blood brain barrier. Additionally, there is no effective treatment for type 2.

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Gaucher's Disease Emerging Therapies

• Venglustat (Sanofi)
• AVR-RD-02 (Avro Bio)
• Venglustat + Imiglucerase (Sanofi)

Gaucher's Disease Market Factors

The key driving factors in the Gaucher's Disease drug market is the increasing incidence of Gaucher's Disease and improved diagnosis. There remains a high unmet need for the development of improved treatments that combat neuropathic complications at reduced costs and a convenient administration schedule.

Gaucher's Disease Market Dynamics

The Gaucher's Disease market dynamics are anticipated to change in the coming years owing to the launch of novel drugs.

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Scope of the Gaucher's Disease Market Report
• Coverage- 7MM
• Study Period- 2019-2032
• Gaucher's Disease Market Companies- Genzyme, Sanofi, Takeda (Shire), and several others.
• Gaucher's Disease Market Drugs included Cerezyme, Eliglustat, Velaglucerase alfa, and several others.

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Table of content
1. Key Insights
2. Executive Summary of Gaucher's disease
3. Competitive Intelligence Analysis for Gaucher's disease
4. Gaucher's disease: Market Overview at a Glance
5. Gaucher's disease: Disease Background and Overview
6. Patient Journey
7. Gaucher's disease Epidemiology and Patient Population
8. Treatment Algorithm, Current Treatment, and Medical Practices
9. Gaucher's disease Unmet Needs
10. Key Endpoints of Gaucher's disease Treatment
11. Gaucher's disease Marketed Products
12. Gaucher's disease Emerging Therapies
13. Gaucher's disease: Seven Major Market Analysis
14. Attribute analysis
15. 7MM: Market Outlook
16. Access and Reimbursement Overview of Gaucher's disease
17. KOL Views
18. Market Drivers
19. Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
23. About DelveInsight

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