Know your NUCLEOTIDES

Nucleotide
Know your NUCLEOTIDES Dr Peter Köppel and Rachel Hoyle investigate the importance of nucleotide nutrition in relation to the gut.
Gut Health8
nucleotides
In Japan, infant formula has been supplemented with nucleotides since 1965, but it took the rest of the world another 20 to 30 years to catch onto the concept. Supplementation of infant formula is reported to have by increasing the count of '1, decreasing the count of enterobacteria, reducing the incidence of diarrhoea2 and modulating immune function3. Yet, the proportion of the population which understands the importance of dietary nucleotides - and that includes those in healthcare professions as well - is miniscule; nearly everyone and carbohydrates (especially complex ones from plant-source foods). In terms of micronutrients, we're all familiar with vitamins and minerals and more are becoming aware of the vital role played by plant compounds (phytonutrients) antioxidants (free radical scavengers) and also help modulate a wide range of key metabolic processes in all our body systems (for example, endocrine, immune, cardiovascular, muscular.
skeletal, brain/nervous system, dermis [skin, hair, nails]). But who's ready to accept another, whole category of nutrient, namely nucleotides? We believe any person who's spent time digesting (pun intended) the science around these nutrients will be convinced. And it's why we feel it's major to know to made the word out far and wide. This has triggered research by us into whether nucleotides are important in adult health and if supplemental nucleotides can enhance health or prevent or treat clinical conditions. WHAT ARE NUCLEOTIDES? DNA is the blueprint of life and nucleotides are the building blocks of the double helix. Nucleotides consist of a nitrogen-containing base (mostly adenine, thymine, cytosine, guanine or deoxyribose) and one to three phosphate groups. FUNCTIONS Obviously, nucleotides are an integral part of the structure of DNA and RNA and are essential compounds in the energy transfer system (i.e. in ATP, NADP, NADH)4, 5, thus it has been assumed that they play an important role in carbohydrate, lipid, protein.

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NUCLEOTIDE SUPPLEMENTATION A number of studies examining the effects of supplemental nucleotides have also been carried out in differing effects. Treatment by dietary nucleotides* has with IBS. *Using a nucleotide supplement containing a balanced formula of pyrimidine and purine nucleotides11. A total of 37 people with IBS found that taking a nucleotide-based supplement (one 500mg capsule three times daily) resulted in a statistically seven symptom scores of IBS compared to placebo11. Namely, abdominal pain, urgency and a feeling of incomplete evacuation. Severity of diarrhoea was also improved. The improvements were modest, as would be expected in a community sample (i.e. not drawn from a clinical trial population), but no adverse side effects were reported. The authors speculate that improved gut function could be via similar mechanisms found in animal studies, namely increased mucosal protein, DNA and villus height.
GRAPH SHOWING SYMPTOM IMPROVEMENTS
CONCLUSION It is clear that nucleotides are involved in many aspects of cellular metabolism, growth and immune function. Their precise mechanism of action remains to be fully understood. The addition of nucleotides to infant formula milk and more recently to enteral food clearly demonstrates a consensus in are essential for normal functioning of the body. It is accepted that dietary nucleotides are conditionally essential under conditions of immunological stress, during periods for disease or injury to the gastrointestinal tract. Much of this research has been carried out in animals, but there are encouraging results from human trials of enteral food, and the independent clinical studies with IBS11, URTI (colds) infections18, stress (intensive19, moderate endurance20 and resistance21). The more we understand about the roles nucleotides play - particularly in areas of the body with rapid cellular turnover rates, most notably the gut mucosa, the gut microbiome, the immune system - the more we felt that nucleotides may not just be 'conditionally essential', but essential for most of us. Our high stress levels, including exercise-induced stress, along with our ever-decreasing nucleotide intake from food sources in the Western diet, and even trauma and injury, will all contribute to dramatically increasing our dietary.

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With Vegana Natura we want to optimize natural nutrition and provide vegan food supplements with important nucleotides. nucleotides! represent the basis of DNA and RNA and are the basic building blocks for cell reproduction, protein synthesis and energy transport. No muscle growth without nucleotides! Better recovery and endurance with nucleotides.

This release was published on openPR.