Hereditary Hemochromatosis (HH) Market to Witness Growth by 2032, Estimates DelveInsight

DelveInsight's "Hereditary Hemochromatosis (HH) Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of Hereditary Hemochromatosis (HH), historical and forecasted epidemiology as well as the Hereditary Hemochromatosis (HH) market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.


The Hereditary Hemochromatosis (HH) market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted Hereditary Hemochromatosis (HH) market size from 2019 to 2032, segmented by seven major markets. The Report also covers current Hereditary Hemochromatosis (HH) treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the Hereditary Hemochromatosis (HH) market.

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Hereditary Hemochromatosis (HH): An Overview

Iron is essential for cell metabolism and is a constituent of hemoproteins, such as hemoglobin, myoglobin, and cytochrome P450. Consequently, total body iron levels are precisely regulated under normal physiologic conditions. Hereditary hemochromatosis (HH) is an autosomal recessive disorder in which iron regulation is disrupted, resulting in the toxic accumulation of iron in vital organs and the development of cirrhosis, bone and joint disease, diabetes mellitus, and heart disease.

Hereditary hemochromatosis disrupts the body's regulation of iron. Men have a 24-fold increased rate of iron-overload disease compared with women. Persons who are homozygous for the HFE gene mutation C282Y comprise 85% to 90% of phenotypically affected persons. End-organ damage or clinical manifestations of hereditary hemochromatosis occur in approximately 10% of persons homozygous for C282Y.

The two types of hemochromatosis are primary and secondary. Each type has a different cause. Primary Hemochromatosis: is caused by a defect in the genes that control how much iron is absorbed from food. Secondary Hemochromatosis: usually is the result of another disease or condition that causes iron overload. Examples of such diseases and conditions include- Certain types of anemia, such as thalassemia and sideroblastic anemia.

Hereditary Hemochromatosis Subtype Classification System: Type 1-classical HFE gene mutation, Type 2-non-classical (also known as juvenile hemochromatosis) resulting from mutations in iron regulatory protein, hemojuvelin (HJV gene), Type 3-non-classical resulting from mutations in the transferrin receptor protein 2 (TFR2 gene) and Type 4-non-classical resulting from mutations in the iron exporter, ferroportin (SLC40A1 gene).

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Hereditary Hemochromatosis (HH) Market

According to the National Organization for Rare Diseases (NORD), hereditary hemochromatosis (HH) is a general term for several rare genetic disorders that are characterized by the accumulation of iron in various organs of the body such as the liver, heart and pancreas. The abnormally stored iron can damage affected organs, potentially causing a variety of different symptoms.

Currently, the treatment paradigm for hereditary hemochromatosis involves purification of blood thereby removing iron in regular intervals. The commonly followed practice for removing iron from the blood is known as Phlebotomy which have obtained approval from US Food and Drug Administration in some blood collection centers in the United States. Initially, the patient undergoes phlebotomy frequently to lower the level of iron. After this initial phase, phlebotomies are performed only as needed to keep iron levels normal. Since mostly body's iron gets accumulated in the RBCs, this may help to lower the iron levels. The removal of blood depends upon age, health and severity in the iron levels. Commonly it is followed for about approximately 2 years till the time iron levels get controlled.


The Hereditary Hemochromatosis (HH) market outlook of the report helps to build a detailed comprehension of the historical, current, and forecasted Hereditary Hemochromatosis (HH) market trends by analyzing the impact of current Hereditary Hemochromatosis (HH) therapies on the market and unmet needs, drivers, barriers, and demand for better technology.

According to DelveInsight, the Hereditary Hemochromatosis (HH) market in 7MM is expected to witness a major change in the study period 2019-2032.


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Hereditary Hemochromatosis (HH) Epidemiology

According to National Institute of Health (NIH), hereditary hemochromatosis is a disorder that causes the body to absorb too much iron from the diet. The excess iron is stored in the body's tissues and organs, particularly the skin, heart, liver, pancreas, and joints. Because humans cannot increase the excretion of iron, excess iron can overload and eventually damage tissues and organs. For this reason, hereditary hemochromatosis is also called an iron overload disorder.

According to the a study by Crooks et al. (2008), Hereditary Hemochromatosis affects males and females in 2:1 ratio.

The Hereditary Hemochromatosis (HH) epidemiology section provides insights into the historical and current Hereditary Hemochromatosis (HH) patient pool and forecasted trends for seven individual major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the Hereditary Hemochromatosis (HH) market report also provides the diagnosed patient pool, trends, and assumptions.


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Hereditary Hemochromatosis (HH) Drugs Uptake

This section focuses on the uptake rate of the potential Hereditary Hemochromatosis (HH) drugs recently launched in the Hereditary Hemochromatosis (HH) market or expected to be launched in 2019-2032. The analysis covers the Hereditary Hemochromatosis (HH) market uptake by drugs, patient uptake by therapies, and sales of each drug.

Hereditary Hemochromatosis (HH) Drugs Uptake helps in understanding the drugs with the most rapid uptake and the reasons behind the maximal use of new drugs and allows the comparison of the drugs based on Hereditary Hemochromatosis (HH) market share and size, which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.


Hereditary Hemochromatosis (HH) Pipeline Development Activities

The Hereditary Hemochromatosis (HH) report provides insights into different therapeutic candidates in Phase II and Phase III stages. It also analyses Hereditary Hemochromatosis (HH) key players involved in developing targeted therapeutics.


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Hereditary Hemochromatosis (HH) Therapeutics Assessment

Major key companies such as Protagonist Therapeutics, Novartis Pharmaceuticals, and others are working proactively in the Hereditary Hemochromatosis (HH) Therapeutics market to develop novel therapies which will drive the Hereditary Hemochromatosis (HH) treatment markets in the upcoming years.

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Hereditary Hemochromatosis (HH) Report Key Insights

1. Hereditary Hemochromatosis (HH) Patient Population
2. Hereditary Hemochromatosis (HH) Market Size and Trends
3. Key Cross Competition in the Hereditary Hemochromatosis (HH) Market
4. Hereditary Hemochromatosis (HH) Market Dynamics (Key Drivers and Barriers)
5. Hereditary Hemochromatosis (HH) Market Opportunities
6. Hereditary Hemochromatosis (HH) Therapeutic Approaches
7. Hereditary Hemochromatosis (HH) Pipeline Analysis
8. Hereditary Hemochromatosis (HH) Current Treatment Practices/Algorithm
9. Impact of Emerging Therapies on the Hereditary Hemochromatosis (HH) Market

Table of Contents

1. Key Insights
2. Executive Summary
3. Hereditary Hemochromatosis (HH) Competitive Intelligence Analysis
4. Hereditary Hemochromatosis (HH) Market Overview at a Glance
5. Hereditary Hemochromatosis (HH) Disease Background and Overview
6. Hereditary Hemochromatosis (HH) Patient Journey
7. Hereditary Hemochromatosis (HH) Epidemiology and Patient Population
8. Hereditary Hemochromatosis (HH) Treatment Algorithm, Current Treatment, and Medical Practices
9. Hereditary Hemochromatosis (HH) Unmet Needs
10. Key Endpoints of Hereditary Hemochromatosis (HH) Treatment
11. Hereditary Hemochromatosis (HH) Marketed Products
12. Hereditary Hemochromatosis (HH) Emerging Therapies
13. Hereditary Hemochromatosis (HH) Seven Major Market Analysis
14. Attribute Analysis
15. Hereditary Hemochromatosis (HH) Market Outlook (7 major markets)
16. Hereditary Hemochromatosis (HH) Access and Reimbursement Overview
17. KOL Views on the Hereditary Hemochromatosis (HH) Market
18. Hereditary Hemochromatosis (HH) Market Drivers
19. Hereditary Hemochromatosis (HH) Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer

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