PD-1 and PDL-1 Inhibitors Market Continues to Grow Due to the Increasing Prevalence of Cancer

PD-1 and PDL-1 inhibitors, a group of immune checkpoint inhibitors, are emerging as a front-line treatment for several types of cancer. The major factor attributing to the growth of the PD-1 and PDL-1 inhibitors market is the increasing prevalence of various cancers along with the growing geriatric population across the world, mainly in developed and emerging economies. According to the World Health Organization (WHO), worldwide, cancer is one of the leading cause of death, accounting for nearly 10 million deaths in 2020. The most common in 2020 (in terms of new cases of cancer) were: breast (2.26 million cases).

The binding of PD-1 to PDL-1 keeps T cells from killing tumor cells in the body (left panel). Blocking the binding of PD-L1 to PD-1 with an immune checkpoint inhibitor (anti-PD-1 or anti-PD-L1) allows the T cells to kill tumor cells (right panel). The United States Food and Drug Administration (FDA) has approved 6 anti–PD-1 and anti-PD-L1 inhibitors, covering 16 cancer indications as monotherapy or in combination with other drugs. PD-1 inhibitors are safe and effective in treating Hodgkin lymphoma, bladder cancer, head and neck cancers, melanoma of the skin, kidney cancer, and non-small-cell lung carcinoma. Thus, there is an increasing demand for PD-1 and PDL-1 inhibitors worldwide.

PD-1 and PD-L1 Inhibitors Market was valued at USD 20.14 Billion in 2020 and is projected to reach USD 77.44 Billion by 2026, growing at a CAGR of 18.24% from 2021 to 2026.

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The major players in the market report are:
Merck, Novartis, Bristol-Myers Squibb, GlaxoSmithKline, Regeneron Pharmaceuticals, Eli Lilly and Company, Roche Genetech, AstraZeneca, Jiangsu HengRui Medicine Co., Ltd., Curis Inc., Aurigene

On the basis of type, the market has been segmented into:
Humanized IgG1(Immunoglobulin 1), Humanized IgG4(Immunoglobulin 5), Cytokine

On the basis of application, the market has been segmented into:
Oral, Subcutaneous Injection

PDL-1 inhibitors are proven to be effective in Merkel cell skin cancer, bladder cancer, and non-small-cell lung carcinoma. This n turn is expected to augment the growth of the PD-1 and PDL-1 inhibitors market. Growth of the market, in North America, is driven by the increasing cases of cancer and the growing geriatric population in the region. According to the National Cancer Institute, in 2020, around 1,806,590 new cases of cancer were expected to be diagnosed in the United States and around 606,520 people were expected to die from the disease. Age is the biggest single risk factor for cancer; risk increases significantly after age 50.

According to the same source, a quarter of new cancer diagnoses are in people aged 65 to 74. Thus, with the growing geriatric population, the demand for PD-1 and PDL-1 inhibitors is also expected to increase with a rapid pace. According to the WHO, the world's population aged 60 years and older is expected to total 2 billion by 2050, up from 900 million in 2015. This in turn is also expected to boost the growth of the PD-1 and PDL-1 inhibitors market, especially in the U.S. These inhibitors are also active in pregnancy following tissue allografts and emerging as a front-line treatment in immunotherapy for several types of cancer.

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