GABA Receptor Antagonists Market: Facts, Figures and Analytical Insights 2021-2030

The GABA Receptor Antagonists Market report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides an in-depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies. We analyzed the impact of COVID-19 (Corona Virus) on the product industry chain based on the upstream and downstream markets, on various regions and major countries and on the future development of the industry are pointed out.

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The report presents the market competitive landscape and a corresponding detailed analysis of the major vendor/key players in the market. Top Companies in the Global GABA Receptor Antagonists Market: Novartis, Servier, Umecrine Cognition, Angelini

Design, Synthesis, and Insecticidal Activity of 5,5-Disubstituted 4,5-Dihydropyrazolo[1,5- a ]quinazolines as Novel Antagonists of GABA Receptors

To control the development of resistance to conventional insecticides acting as γ-aminobutyric acid (GABA) receptor antagonists (e.g., fipronil), new GABAergic 5,5-disubstituted 4,5-dihydropyrazolo[1,5-a]quinazolines were designed via a scaffold-hopping strategy and synthesized with a facile method. Among the 50 target compounds obtained, compounds 5a, 5b, 7a, and 7g showed excellent insecticidal activities against a susceptible strain of Plutella xylostella (LC50 values ranging from 1.03 to 1.44 μg/mL), which were superior to that of fipronil (LC50 = 3.02 μg/mL). Remarkably, the insecticidal activity of compound 5a was 64-fold better than that of fipronil against the field population of fipronil-resistant P. xylostella. Electrophysiological studies against the housefly GABA receptor heterologously expressed in Xenopus oocytes indicated that compound 5a could act as a potent GABA receptor antagonist, and IC50 was calculated to be 32.5 nM. Molecular docking showed that the binding poses of compound 5a with the housefly GABA receptor can be different compared to fipronil, which explains the effectiveness of compound 5a against fipronil-resistant insects. These findings have suggested compound 5a as a lead compound for a novel GABA receptor antagonist controlling field-resistant insects and provided a basis for further design, structural modification, and development of 4,5-dihydropyrazolo[1,5-a]quinazoline motifs as new insecticidal GABA receptor antagonists.

Market Segmentation:

Key Products

 SGS 742
 Afizagabar
 Golexanolone
 Gabapentin/trazodone hydrochloride and others. 

Market Overview:

Gamma-aminobutyric acid (GABA) inhibitors, or GABA antagonists, are drugs which inhibit the action of GABA, the primary inhibitory neurotransmitter of the central nervous system. They predominantly work at the GABA receptor. GABA receptors categorize into the GABA-A receptor and GABA-B receptor subtypes. There also exists a GABA-C receptor, but it is typically classified as a subtype of GABA-A receptors and named GABA-A-rho. While GABA-A receptors are ionotropic receptors that gate chloride channels, GABA-B receptors are metabotropic G-protein coupled receptors. The receptor subtypes can also be differentiated based on their selectivity to agonists and antagonists: GABA-A receptors are antagonized by bicuculline and insensitive to baclofen, whereas GABA-B receptors are agonized by baclofen and insensitive to bicuculline. The potency of most GABA-A receptor antagonists is mostly independent of receptors subunit composition, in contrast to GABA-A receptor agonists.

Examples of GABA-A receptor antagonists include flumazenil, bicuculline, picrotoxin/picrotoxinin, gabazine, suramin, sepranolone, salicylidene salicylhydrazide (SCS), bilobalide, RU5135, and 4-(3-biphenyl-5-(4-piperidyl)-3-isoxazole (3-biphenyl-4-PIOL). Examples of GABA-C receptor antagonists include 1,2,5,6-Tetrahydropyridin-4-methylphosphinic acid (TPMPA).

GABA receptor antagonists produce convulsant and stimulant effects and mainly have a use for research purposes. For example, bicuculline and gabazine are frequently used to dissect GABA-A receptor components in neurons functionally. These GABA receptor antagonists act as subtype-selective compounds and help to study the behavioral effects of the different GABA-A receptor subtypes.

The major inhibitory neurotransmitter in the central nervous system (CNS) is the gamma_amino butyric acid (GABA). Inhibition is mediated by the ionotropic and metabotropic receptors, located pre or postsynaptically.

GABA Receptor Antagonists Emerging Drugs Chapters

This segment of the GABA Receptor Antagonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Influence Of The GABA Receptor Antagonists Market Report:

-Comprehensive assessment of all opportunities and risk in the GABA Receptor Antagonists market.

- GABA Receptor Antagonists market recent innovations and major events.

-A Detailed study of business strategies for growth of the GABA Receptor Antagonists market-leading players.

-Conclusive study about the growth plot of GABA Receptor Antagonists market for forthcoming years.

-In-depth understanding of GABA Receptor Antagonists market-particular drivers, constraints and major micro markets.

-Favorable impression inside vital technological and market latest trends striking the GABA Receptor Antagonists market.

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What Are The Market Factors That Are Explained In The Report?

Key Strategic Developments: The study also includes the key strategic developments of the market, comprising R&D, new product launch, M&A, agreements, collaborations, partnerships, joint ventures, and regional growth of the leading competitors operating in the market on a global and regional scale.

Analytical Tools: The Global GABA Receptor Antagonists Market Report includes the accurately studied and assessed data of the key industry players and their scope in the market by means of a number of analytical tools. The analytical tools such as Porter’s five forces analysis, SWOT analysis, feasibility study, and investment return analysis have been used to analyze the growth of the key players operating in the market.

Key Market Features: The report evaluated key market features, including revenue, price, capacity, capacity utilization rate, gross, production, production rate, consumption, import/export, supply/demand, cost, market share, CAGR, and gross margin. In addition, the study offers a comprehensive study of the key market dynamics and their latest trends, along with pertinent market segments and sub-segments.

The report has 150 tables and figures browse the report description and TOC:

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