2020-2025 Neoantigen Targeted Therapies Market to witness astonishing growth with Top Key Players – MediGene, Bavarian Nordic, Genocea Biosciences, Gradalis, Immunicum, Neon Therapeutics
The report covers a forecast and an analysis of the Neoantigen Targeted Therapies Market on a global and regional level. The study provides historical data for 2015, 2016, 2017 and 2018 along with a forecast from 2020 to 2025 based on revenue (USD Million) and volume (Kilotons). The study includes drivers and restraints of the Neoantigen Targeted Therapies Market along with the impact they have on the demand over the forecast period.
According to the market research study, Neoantigen Targeted Therapies help in curing cancer by improving the response of immune system and generating new immune responses. Furthermore, recent developments in genomic analysis and advances in bioinformatics have enabled the adoption of more personalized treatment approaches, such as Neoantigen Targeted Therapies. Cancer neoantigens is a term used to refer to a subset of antigens encoded by tumor-specific, mutated genes, which have not previously been recognized by host's immune system. Currently, several neoantigen-based therapies are being investigated in combination with various immune checkpoint inhibitors, such as atezolizumab, durvalumab, ipilimumab and nivolumab. In fact, multiple such initiatives by start-ups are backed by venture capital firms and other strategic investors.
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In terms of the regional analysis, North America is anticipated to lead in terms of market share during the forecast period. This is mainly because of presence of maximum consumer pool in the region. Furthermore, factors such as well-developed healthcare infrastructure, early adoption of advanced technology, and favorable government reimbursement plan are expected to play a significant role in the growth of the Global Neoantigen Targeted Therapies Market.
This report contains a complete product overview and its scope in the market to define the key terms and provide the clients a holistic idea of the market and its tendency. It comprehensively evaluates the Global Neoantigen Targeted Therapies Market with different perspectives for the purpose of providing a detailed, informative, and accurate analysis of regional growth, competition, market segmentation, and other important aspects.
Global Key Players:
1 Bavarian Nordic
2 Genocea Biosciences
5 Immunovative Therapies
6 Iovance Biotherapeutics
8 Neon Therapeutics and More………………
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Product Type Segmentation
2 Combination Therapy
1 Medical Research Institution
2 Hospital and Clinic
Global Medical Industry News:
Medigene (June 23, 2020) - Medigene enters Phase I clinical development with its TCR-T immunotherapy MDG1021 in hematological cancers - Medigene AG, a clinical stage immuno-oncology company focusing on the development of T cell immunotherapies, has received approval from the Dutch regulatory authority (the Central Committee on Research Involving Human Subjects, CCMO) to begin a first clinical trial of MDG1021. MDG1021, which targets the antigen HA-1, thus becomes Medigene's second proprietary T cell receptor-modified T cell (TCR-T) immunotherapy candidate to enter clinical development. The Phase I study of MDG1021 will be initiated at the Leiden University Medical Center (LUMC), the Netherlands, and will enroll patients suffering from relapsed or persistent blood cancers after allogeneic (non-self) hematopoietic stem cell transplantation (allo-HSCT), an area with high unmet medical need.
Currently, patients suffering from blood cancers are treated with chemotherapy. Where possible this chemotherapy is followed by an allo-HSCT as the preferred treatment option where the donor stem cells re-establish a blood forming system in the patient. However, patients who suffer from a relapse of their cancers after allo-HSCT currently have few treatment options.
MDG1021 is a TCR-T immunotherapy targeting a specific, immunogenic form of the antigen HA-1. HA-1 is exclusively expressed on cells of the hematopoietic system. If the patient's blood-cells, and thus lymphoma or leukemic cells, carry the immunogenic version of the HA-1 antigen on their surface and the donor stem cells do not, MDG1021 TCR-T cells could eradicate the patient's cancer cells and allow the donor stem cells to repopulate the patient's blood forming system.
Phase I trial design: According to the clinical trial authorization, the trial will assess the safety and feasibility of MDG1021 immunotherapy, with secondary endpoints including preliminary efficacy. In the dose-escalation portion of the trial, at least 9 patients will be treated with MDG1021 at 3 different doses to assess the safety and the maximum tolerated dose using a standard 3+3 cohort design. MDG1021 will be administered as a single IV infusion.
After each dose cohort, safety data will be assessed by an independent data and safety monitoring board. Upon completion of the dose escalation part and selection of the optimal dose, an expansion part of the study will evaluate MDG1021's safety in 20 additional patients.
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Major Points in Table of Contents:
Global Neoantigen Targeted Therapies Market Report 2020
1 Neoantigen Targeted Therapies Product Definition
2 Global Neoantigen Targeted Therapies Market Manufacturer Share and Market Overview
2.1 Global Manufacturer Neoantigen Targeted Therapies Shipments
2.2 Global Manufacturer Neoantigen Targeted Therapies Business Revenue
2.3 Global Neoantigen Targeted Therapies Market Overview
2.4 COVID-19 Impact on Neoantigen Targeted Therapies Industry
3 Manufacturer Neoantigen Targeted Therapies Business Introduction
3.1 Bavarian Nordic Neoantigen Targeted Therapies Business Introduction
3.2 Genocea Biosciences Neoantigen Targeted Therapies Business Introduction
3.3 Gradalis Neoantigen Targeted Therapies Business Introduction
3.4 Immunicum Neoantigen Targeted Therapies Business Introduction
3.5 Immunovative Therapies Neoantigen Targeted Therapies Business Introduction
3.6 Iovance Biotherapeutics Neoantigen Targeted Therapies Business Introduction
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