Tumor Organoids to Drive Personalized Cancer Treatment Market

The current scenario of the medical world represents the boundation by the constructs of the very traditional models for the care delivery and the limitation for the doctors to prescribe the therapies that are based on population averages. This results in an inefficient care system with a significant portion of healthcare failure in majority of the population. However, as per our research report " Global Cancer Tumor Organoids Modeling, Technology & Personalized Cancer Research Insight 2025" findings, the idea of developing organoids from the cancer cells is causing the level of healthcare system to initiate the process of evolution and transform the basis of the medical care based on the population averages to individual patient.

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Cancer organoids can be defined as the mini-version of the three-dimensional structures that are derived from the organ restricted stem cells or from pluripotent cells harboring the capacity to recapitulate the in vivo architecture of the tissues that are terminally differentiated. Cancer organoids have recently been recognized as a potential and promising therapeutic approach for the treatment of cancer. The idea of developing organoids from the cancer cell sample represents a major milestone that is en-routing the path towards the successful personalized medicine for each and every sector in the healthcare. The mini version of the parent cancer provides information about the current status of the progression of cancer and summarizes their potential towards the development of personalized medicine.

The partial effectiveness and safety of the already available drugs and other cancer treatment techniques has made it possible to develop this novel therapeutic approach for research world and all the emerging markets. Large amount of money is getting invested in the technique which directly aims at improving the technique and taking the approach to another level. The current research about the organoids is favoring the idea of developing personalized medication. The ongoing clinical research and the emergence of the respective approach in developed countries such as US, Europe and Taiwan is expected to shoot the price of the healthcare system but more than that it will result in a drastic revolution in the healthcare system and especially toward the personalized medicine in a positive way.

The development of this novel therapeutic approach is followed by thousands of clinical trials undergoing in some of the developed countries like US, Japan and afterwards followed by Europe. The approach of developing organoids from the cancer cells and further applied it for the development of personalized medicine is widely supported by the large and small scale pharmaceuticals, biotech firms and research institute in the current scenario. With the advent of the approach in the market of US, Japan and Europe and Rest of World, the new era of cancer treatment will be personalize to each and every patient and will be an ideal deal that cannot be neglected. The effectiveness of the approach and its ability to experience the effect of various technologies available prior to the various therapies will drive their demand in the pharmaceutical market.

Cellesce, MIMETAS, Hubrecht Organoid Technology, Crown Biosciences and Atomwise are some of the major key players of the market that are deeply involved in expanding the approach among all the markets. According to our intense research about the approach, we understand that the respective therapeutic approach holds a quite promising future for personalizing the treatment according to the patient and undoubtedly will experience a magnificent commercial success. Furthermore, the ongoing clinical research and the trails underway represent a favorable future for the cancer organoids. In general, the future of the approach depicts the continuous growth and a huge commercial success and the establishment of the novel and promising approach in every sector of healthcare.

Report Table of Contents

1. Introduction to Organoids
1.1 Organoids
1.2 History of the Development
1.3 Timeline for Patient Derived Tumor Organoid (PDTO) Development

2. Cancer Organoids: Promising Tool for Cancer Biologists
2.1 Cancer Organoids Revealing the Cancer Dynamics
2.2 Cancer Organoids: An Intermediate Platform for Targeted Therapy

3. Human Cancer Modeling
3.1 Growth Factors & Small Molecule Inhibitors Applied In Organoid Cultures
3.2 Culture Systems of Multiple Tumoroids
3.3 Human Organoid Protocol
3.4 Extraction Methods for Initiating an Organoid Generation
3.4.1 Biopsy
3.4.2 Surgery

4. Establishment of Cancer Organoids
4.1 In-vitro Establishment of Stomach Cancer Organoid Cancer
4.2 Invasion of In-Vivo Mutations in In-Vitro Organoid Model of Intestinal Cancer
4.3 Expansion of Liver Cancer Organoids in the Laboratories
4.4 In- Vitro Modeling of Pancreatic Cancer Organoid
4.5 Transformation of Breast Cancer Cells into Organoids
4.6 3D Organoid Model Generation for Bladder Cancer
4.7 Obtaining In-Vitro Model of In-Vivo Prostate Cancer
4.8 Miniature Organ Development from the In-Vivo Ovarian Cancer Cells
4.9 Creation of In-Vivo Esophageal Cancer as an In-Vitro Organoid Model


5. Cancer Organoids & Other Laboratory Techniques to Assess Treatment Responses
5.1 Cell Lines
5.2 Patient-Derived Xenografts
5.3 Organotypic Tissue Slice Culture
5.4 Cancer Organoids: Marking a New Territory

6. Tumors Organoids Accelerating Cancer Treatment
6.1 Cancer Epidemic & Pre-Screening
6.2 Cancer Organoids Predicting Tumor Responses

7. Advantages of Cancer Organoids
7.1 Reduction in Experimental Complexity Through Cancer Organoids Models
7.2 Similar Genetic Representation between the Organoid & Parent Tumor Organ
7.3 Cancer Organoid Models Predicting the Response of Cancer Treatment
7.4 Cancer Organoid Models Retaining the Phenotype of Parent Organ after Development
7.5 Cancer Organoid Models Supporting Biomarker Profiling in Cancer Research

8. Cancer Organoids: Advanced Research & Therapeutic Potential
8.1 Cancer Organoids: Revolutionizing Novel Anti-Cancer Drug Testing Methodology
8.2 Mini-Organ Toxicity Demonstration by Cancer Organoids
8.3 Pharmacokinetics & Pharmacodynamics Analysis Enabled by Cancer Organoids
8.4 Cancer Organoids: Innovations in Drug Development Method
8.5 Cancer Organoids as a Potential Platform for Personalized Cancer Therapy

9. Organoid Development Transforming Basic Medical Research
9.1 Organoids Advancement in Organ Replacement
9.2 Analyzing Gene Therapy on Organoids
9.3 Organoids for Cell Therapy Analysis


10. Post-Model Generation Screening of Cancer Organoids
10.1 Identical Genetic Characteristics between Cancer Organoid & Parent Organ
10.2 Maintaining the Histology of Cancer Organ Tissues
10.3 Tumorigenic Characteristic Screening of Cancer Organoids

11. Patient-Derived Tumor Organoids & its Achievement in Medical Research
11.1 Translational Application of Cancer organoid Models
11.2 Cancer Organoids Promoting Oncogenic Mutation Study
11.3 Integration of the Microenvironment Induced by Cancer Organoids

12. CRISPR-Cas9 Potential Applications in Cancer Organoids
12.1 CRISPR-Cas9: A Promising Gene Editing Technology
12.2 CRISPR-Cas9 Mediated Cancer Organoid Technology
12.3 CRISPR Based Gene Edited Organoids Recapitulating Cancer Mutations

13. Organoids for the Study of Pancreatic Cancer
13.1 Human Endocrine & Exocrine Cancer Pancreatic 3D Model to Transform Cancer Treatment
13.2 Development of Pancreas 3D Cancer Organoid System
13.3 Applications of 3D Pancreatic Organoid Culture
13.3.1 Pancreatic Cancer Organoid & Genetic Implementation
13.3.2 Pancreatic Cancer Organoid & the Inner Environment Benefits
13.3.3 Pancreatic Cancer Organoid Model for Drug Toxicity Screening
13.3.4 Pancreatic Cancer Organoid Provoking Personalized Therapy

14. Organoids for the Study of Stomach Cancer
14.1 Development of Stomach Cancer Organoid Culture
14.2 High-Throughput Screening with Stomach Cancer Organoid 3D Model
14.2.1 Tumorigenesis with Stomach Cancer Organoids
14.2.2 Stomach Cancer Organoids Screening Drug Sensitivity
14.2.3 Developing Stomach Cancer Biobanks for Drug Screening
14.2.4 Stomach Cancer Organoids for Personalizing Therapy

15. Three-Dimensional Culture of Liver Organoid in Cancer Biology
15.1 Development of Liver Organoids
15.2 Progress & Potential of Organoid Towards Liver Cancer
15.2.1 Liver Cancer Organoids as a New Model for Improving Drug Screening
15.2.2 Primary Liver Cancer Organoids for Novel Drug Discovery
15.2.3 Primary Liver Cancer Organoids Creating the Living Biobank for the Future Therapeutic Challenges
15.2.4 Primary Liver Cancer Organoids Transforming Personalized Therapy

16. Advanced Development of Breast Cancer Organoids
16.1 Organoid Technology to Transform Breast Cancer Modeling & Development
16.2 An Organoid Approach Marking Breast Cancer Therapeutic Research
16.2.1 Breast Cancer Organoids in Drug Development & Expansion
16.2.2 Breast Cancer Organoids: An in-vitro Model for Cancer Biomarker Discovery
16.2.3 Breast Cancer Organoids as a Powerful Resource for Personalized Therapy

17. Kidney Cancer Organoids for Cancer Research & Therapeutic Challenges
17.1 Kidney Cancer Organoids: Developmental Approach & Characteristics Analysis
17.2 Organoid Technology & its Applications in Treating Kidney Cancer
17.2.1 Kidney Cancer Organoids Actively Participating in the Pre-Clinical & Clinical Trials
17.2.2 Validation of Cancer Biomarkers by Kidney Cancer Organoids in Drug Development

18. Organoids for the Development of Lung Cancer
18.1 Generation of Lung Cancer Organoid from Lungs Tissue
18.2 Lung Cancer Organoids: A Novel 3D Platform for Therapeutic Research
18.2.1 Lung Cancer Organoids for Therapeutic Screening & Cancer Research
18.2.2 Organoids Re-Creating the Treatment for Lung Cancer


19. Ovarian Cancer Organoids & its role in Therapeutic Advancement
19.1 Organoid Model Recapitulating Human Ovarian Cancer
19.2 Validation of Potential Benefits Received from Patient-Derived Ovarian Cancer Organoid Model
19.2.1 Editing of Oncogenes in the Patient Derived Ovarian Cancer Organoids
19.2.2 Screening & Drug Testing on Human Ovarian Cancer Organoid Model
19.2.3 Ovarian Cancer Organoids in Modeling the Ovarian Cancer Development & Progression

20. An Organoid Platform for Oncological Research in Bladder Cancer
20.1 Establishment of High-Resolution 3D Organoid Model for Bladder Cancer
20.2 Efficient Use of 3D Bladder Cancer Organoids in Oncology Landscape
20.2.1 3D Bladder Cancer Organoids at an Uprising Scale for Drug Discovery
20.2.2 Testing & Screening of Drugs using Bladder Cancer Organoids
20.2.3 Patient-Derived Bladder Cancer Organoids Predicting Response to Various Cancer Treatments

21. Human Primary Head & Neck Cancer: An Organoid Approach for In-depth Clinical Research
21.1 Generation & Culture of 3D Head & Neck Cancer Organoids
21.2 Patient-Derived Head & Neck Cancer Organoids Re-defining the Cancer Research
21.2.1 Broad Activity of Head & Neck Cancer Organoids towards Cancer Modeling
21.2.2 Transformation of Drug Development & Drug Efficacy Strategies in Head & Neck Cancer using Organoid Technology

22. Living Biobanks of Cancer Organoids Representing Histopathological Diversity
22.1 The Potential of Living Biobank towards Precision Medicine
22.2 Living Bio-banking Strategy Offering Novel Therapeutics for Basic & Advanced Cancer Research

23. Drivers & Challenges Associated with Cancer Organoids
23.1 Drivers Witnessing the Growth of Cancer Organoid Technology
23.2 Challenges Concerning the Growth of Cancer Organoids

24. Future Directions of Organoids in Cancer Research

25. Strategic Joint Ventures by Pharma Companies to Accelerate Drug Discovery through Organoids
25.1 Expanded Breast Cancer Organoids License Agreement between Cellesce & Hubrecht Organoid Technology
25.2 Pre-Clinical Anti-Cancer Drug Development between HUB Organoid Technology & Crown Biosciences
25.3 SEngine’s & Atomwise’s New Joint Venture to Boost Drug Discovery through Organoids

26. Clinical Trials Registered under Cancer Organoids
26.1 Lung Cancer
26.1.1 Clinical Trial - Patient-Derived Organoids of Lung Cancer to Test Drug Responses
26.1.2 Clinical Trial - Patient-Derived Organoid Model & Circulating Tumor Cell for Treatment Responses of Lung Cancer
26.1.3 Clinical Trial - Drug Sensitivity Correlation between Patient-Derived Organoid Model & Clinical Responses in Non-Small Cell Lung Cancer Patients
26.2 Breast Cancer
26.2.1 Clinical Trial – Clinical Study on Drug Sensitivity Verification or Prediction for Breast Cancer by Patient-Derived Organoid Model
26.3 Pancreatic Cancer
26.3.1 Clinical Trial – Drug Screening of Pancreatic Cancer Organoids Developed from EUS-FNA Guided Biopsy Tissues
26.4 Esophageal Cancer
26.4.1 Clinical Trial - Chemoradioresistnace in Prospectively Isolated Cancer Stem Cells in Esophageal Cancer – Organoid: RARE STEM Organoid

27. Current Market Scenario of Cancer Organoid Technology
27.1 Market Trends
27.2 Market Overview
27.2.1 North America
27.2.2 Europe
27.2.3 Asia-Pacific

28. Competitive Landscape
28.1 Cellesce
28.2 MIMETAS
28.3 Hubrecht Organoid Technology
28.4 Crown Biosciences
28.5 Atomwise
28.6 STEMCELL Technologies
28.7 Qgel
28.8 OcellO
28.9 DefiniGEN

Contact:
Neeraj Chawla
neeraj@kuickresearch.com
+91-11-47067990

ANSAL BUILDING
Delhi 110009

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