Spinal Muscular Atrophy Market Latest Report with Forecast to 2026 | Biogen, Cytokinetics, F. Hoffmann-La Roche, Novartis AG, Pfizer

Spinal muscular atrophy (SMA) is a genetic disorder that affects the control of muscle movement. It is caused due to loss of specialized nerve cells, called motor neurons, in the spinal cord and brainstem. The loss of motor neurons leads to weakness and atrophy of muscles used for activities such as sitting up, walking, crawling, and controlling head movement. In severe cases, the muscles used for swallowing and breathing are also affected. There are four types of spinal muscular atrophy, which are differentiated based on the severity of muscle weakness, pattern of features, and age, when the muscle problems begin. These are classified as type 1, 2, and 3 that appears in childhood. Type 4 appears in adulthood and is also termed as adult onset SMA.

The global spinal muscular atrophy market size was valued at US$ 884 million in 2017 and is expected to witness a robust CAGR of 12.4% over the forecast period (2018–2026).

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Market Dynamics

Major factors driving growth of the spinal muscular atrophy market includes increasing number of clinical trials and rising government support for R&D. Biotechnology and biopharmaceutical companies are working towards development of effective therapies to treat spinal muscular atrophy. For instance, in 2016, the U.S. FDA approved Spinraza (nusinersen) drug from Biogen for the treatment of SMA. Spinraza targets the underlying defect in SMA, so it can help prevent, delay, or even reverse the symptoms.

However, its common side effects include higher risk of constipation and respiratory tract infection along with minimal risk of kidney problems and bleeding. Moreover, the cost of research for development of new therapy is also high. With the advancements of drug in the pipeline, its expense and time for development also increases. According to Cure SMA, it can take over 15 years and US$ 100 million for a single drug candidate to reach FDA approval. These factors make research challenging particularly for a disease such as SMA. These factors are expected to hinder growth of the market.

Key features of the study:

This report provides in-depth analysis of spinal muscular atrophy market and provides market size (US$ Million) and Compound Annual Growth Rate (CAGR %) for the forecast period (2018 – 2026), considering 2017 as the base year
It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrix for this market
This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends, regional outlook, and competitive strategy adopted by the leading players
Increasing incidence rate of spinal muscular atrophy worldwide is expected to augment the market growth

Spinal muscular atrophy mainly manifests early in life and therefore is a major genetic cause of death in infants. It is one of the most common rare diseases. According to SMA Foundation 2015 statistics, spinal muscular atrophy has generally been believed to affect as many as 10,000 to 25,000 adults and children in the U.S. In March 2018, CureSMA stated that SMA affects around 1 in 11,000 children, and 1 in 50 is a carrier of the disease. It has been found in people of every race, however, is most common in Caucasians, of whom 1 in 35 is a carrier. Spinal muscular atrophy carrier rates for other populations include Asians (1 in 53), African Americans (1 in 66), and Hispanics (1 in 117).

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