05-17-2011 08:16 AM CET - Health & Medicine

Liver Disease Diagnostics by Immunoblot Test System

Press release from: ORGENTEC Diagnostika
All reagents of Liver-9-Line are ready for immediate use. – © ORGENTEC Diagnostika, Mainz
All reagents of Liver-9-Line are ready for immediate use. – © ORGENTEC Diagnostika, Mainz
Mainz based ORGENTEC Diagnostika GmbH has developed a new immunoblot test for the serological diagnosis of autoimmune liver disease.

Liver-9-Line facilitates the rapid and cost-effective diagnosis of autoimmune hepatitis (type 1 and type 2 AIH) and primary biliary cirrhosis (PBC) in a single step. The test system also allows for the reliable differentiation of these autoimmune diseases from other diseases of the liver. This immunoblot is suitable for initial and differential diagnosis in cases of ambiguous symptomatology or for differentiation of a positive result from screening carried out with ELISA or immunofluorescence tests.

The comprehensive set of antigens included in this new immunoblot is unique on the market: In addition to the three ASMAs, F-actin, myosin, and desmin, Liver-9-Line also detects antibodies against soluble liver antigen (SLA/LP), liver kidney microsomal type 1 (LKM-1), and liver cytosol antigen type 1 (LC1). The PBC-typical autoantibodies detected by this immunoblot include AMA-M2 as well as antibodies against Sp100 and gp210.

The analytical software from ORGENTEC Diagnostika allows for the automated evaluation of the immunoblots. The iVISION Scanware makes it possible to objectively analyze and securely archive test data.

Overview of the antigens used in the Liver-9-Line test: M2, Sp100, gp210, SLA/LP, LKM-1, LC1, F-actin, desmin, myosin. Liver-9-Line is available in packages of 8 or 16 immunoblot strips, all reagents are ready for immediate use. Each individual blot strip includes serum, conjugate control, and cut-off control, as well as an individual code that eliminates accidental mix-ups. - www.orgentec.com

About ORGENTEC Diagnostika:
ORGENTEC Diagnostika GmbH is based in Mainz and is a global leader in the development, production, and marketing of test systems for laboratory diagnostics. ORGENTEC Diagnostika has developed over 200 different test systems for autoimmune diagnostics and the diagnosis of infectious disease. Many of these tests are patent-protected. At the company’s headquarters in Mainz, ORGENTEC Diagnostika now employs over 120 people. With its own distribution channels in Germany, Austria, Switzerland, Hungary, and France, as well as an established global distribution network, ORGENTEC Diagnostika’s products and laboratory tests are benefitting patients in over 100 countries around the world. - www.orgentec.com

ORGENTEC Diagnostika GmbH
- Public Relations -
Tobias Stolzenberg
Dr. Friederike Hammar
Carl-Zeiss-Straße 49-51
55129 Mainz, GERMANY

Tel. +49 6131 9258-677, -674
Fax +49 6131 9258-58


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