In-situ Hybridization Market Latest Advancements & Market Outlook 2018 to 2026 | Abbott Laboratories, Agilent Technologies, Thermo Fisher Scientific And Others

In-situ hybridization is a laboratory procedure that allows researchers to locate the position of specific DNA/RNA sequences in chromosomes. Molecular hybridization is based on the ability of DNA helix to re-form or re-nature when provided with favorable conditions. In molecular hybridization technique, a labeled DNA or RNA sequence is utilized as a probe to identify/locate or quantify the naturally occurring DNA or RNA sequence in a biological sample. Nucleic acid probe is synthesized, labeled, purified, and annealed with the specific target. It is an important technique in genetic research and finding gene-based medicine especially in personalized medicine.

In-situ hybridization is classified on the basis of types of probes, fluorescence in-situ hybridization (FISH), in which fluorescence probe is used and chromogenic in-situ hybridization (CISH). FISH allows to visualize multiple targets in the same sample and is primarily applicable for detecting presence of particular gene, number of copies of gene in sample, and mutation analysis. CISH enables to gain genetic information in the context of tissue morphology and is primarily applicable in case of molecular pathology diagnostics.

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In-situ Hybridization Market- Dynamics

In situ hybridization, especially FISH which has human applications are principally utilized for clinical diagnosis of chronic diseases such as cancer, immune diseases, and certain rare diseases caused due to chromosome abnormalities. Therefore, rising incidence of cancer globally is expected to be one of the major factors driving growth of the in-situ hybridization market. FISH technique is used to identify mutating gene in patients with the help of dedicated assay kits available from key players.

In-situ Hybridization Market- Regional Insights

On the basis of geography, the global in-situ hybridization market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America is expected to hold dominant position in the in-situ hybridization market over the forecast period. U.S. has high incidence of different types of cancer. According to the American Cancer Society factsheet published in 2018, cancer is the second leading cause of death after cardio vascular disease.

In-Situ Hybridization Market- Competitive Landscape

Key players operating in the global in-situ hybridization market include Abbott Laboratories, Inc., Agilent Technologies, Inc., Thermo Fisher Scientific, Inc., F. Hoffmann-La Roche AG, Merck KGaA, PerkinElmer, Inc., Oxford Gene Technology, Leica Biosystems Nussloch GmbH, Exiqon A/S, BioGenex Laboratories, Inc., Advanced Cell Diagnostics, Inc., and Bio SB Inc.

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Key players are launching new products in in-situ hybridization market.

In June 2018, Agilent Technologies Inc. launched a new FISH and CISH probes for in-situ hybridization. The new probes address the need to cleanly and accurately interpret data from both fluorescence in-situ hybridization (FISH) and chromogenic in-situ hybridization (CISH).
In 2016, Oxford Gene Technology, which is a molecular genetics company, launched two new CE-IVD labelled fluorescence in-situ hybridization (FISH) probes, further expanding for lung cancer diagnosis. The Cytocell Aquarius ROS1 Plus Breakapart and RET Breakapart probes specifically and accurately detect rearrangements in the genome associated with non-small cell lung cancer.

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