Avascular Necrosis Market Overview, Development By Companies And Comparative Analysis By 2026 | Bone Therapeutics, Boehringer Ingelheim GmbH, Bayer AG, Enzo Biochem, Ethicon, Eli Lilly

Avascular necrosis (AVN), also called osteonecrosis, ischemic bone necrosis, or aseptic necrosis, is a condition that occurs due to loss of blood flow to the bone. The condition mostly occurs in the hip however, other common sites include ankle, knee, and shoulder. Individuals between the age of 20 and 50 years are more susceptible to avascular necrosis. Most cases of avascular necrosis occur due to an underlying health problem or injury. Moreover, factors such as increased intake of corticosteroids and alcohol may cause fatty substances to build in the blood vessels and decrease the blood supply to the bones, eventually causing avascular necrosis. Treatment for this condition depends on a number of factors, including age, disease stage, location, and amount of bone damage.

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Market Dynamics
Growth of avascular necrosis market is primarily driven by factors such as increasing incidence of avascular necrosis, high demand for non-invasive treatment, and increasing dependence on surgery to cure avascular necrosis. According to Bone Therapeutics report in 2017, around 170,000 patients were suffering from avascular necrosis in the U.S., Europe, and Japan. Moreover, side effects from various medicines taken during cancer, HIV/AIDS, osteoporosis, osteoarthritis, blood disorders, or medical treatment such as chemotherapy, radiation therapy, high-dosage of steroids, and organ transplants can increase chances of developing avascular necrosis. However, delay in diagnosis due to asymptomatic nature of this condition at early stage and high cost of surgical treatments for avascular necrosis are the major factors hampering growth of the avascular necrosis market.

Key features of the study:
• This report provides in-depth analysis of the avascular necrosis market, market size (US$ Mn), and Compound Annual Growth Rate (CAGR (%)) for the forecast period: 2018 – 2026, considering 2017, as the base year
• It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market
• This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends, regional outlook, and competitive strategies adopted by leading players
• It profiles key players in the global avascular necrosis market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments, and strategies

Detailed Segmentation:
• Global Avascular Necrosis Market, By Type:
◦ Trauma Related Avascular Necrosis
◦ Non-Trauma Related Avascular Necrosis
• Global Avascular Necrosis Market, By Treatment:
◦ Drug Based
◦ Surgery

Increasing Alcohol Consumption and Use of Corticosteroids are Expected to Drive Growth of the Avascular Necrosis Market
Excessive alcohol consumption and long-term, high dose systemic corticosteroid use are the major risk factors for avascular necrosis. According to World Journal of Orthopedics, 2015, avascular necrosis usually affects people between 30 and 50 years of age. Also, from the same source, about 10,000 to 20,000 people develop osteonecrosis each year in the U.S. According to National Organization for Rare Disorders’ 2015 data, alcohol consumption and corticosteroid use affects about 30% and 35% of all people with non-traumatic avascular necrosis, respectively across the globe.
Other risk factors or conditions associated with non-traumatic osteonecrosis include autoimmune disease, cancer, decompression disease (Caisson disease), Gaucher disease, pancreatitis, HIV infection, and blood disorders such as sickle cell disease. Certain medical treatments including radiation therapy and chemotherapy can also cause osteonecrosis. Moreover, people who have undergone organ transplants are at high developmental risk of osteonecrosis.

Avascular Necrosis Market - Competitive Landscape
Key players operating in the global avascular necrosis market include Bone Therapeutics, Boehringer Ingelheim GmbH, Bayer AG, Enzo Biochem Inc., Ethicon Inc., Eli Lilly and Company, Grifols SA, Integra LifeSciences Corporation, K-Stemcell Co Ltd., Medtronic Plc, Merck KGaA, Pfizer Inc., Sanofi SA, Stryker Corporation, Wright Medical Group N.V., and Zimmer Biomet Holdings. Manufacturers are focusing on advancements in treatment technologies such as gene therapy and stem cell-based treatment for avascular necrosis.

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