Mucopolysaccharidosis I (MPS I) (Hurler Syndrome) Therapeutics - Pipeline Analysis 2018 | Sangamo Therapeutics, Inc., CRISPR Therapeutics
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Later on, these were clubbed as one disease, due to overlap between each of these three syndromes. Children with MPS I often have no signs or symptoms of the condition at birth, although some may have a soft out-pouching around the belly-button (umbilical hernia) or lower abdomen (inguinal hernia).
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People with severe MPS I generally begin to show other signs and symptoms of the disorder within the first year of life, while those with the attenuated form have milder symptoms that develop later in childhood. Common symptoms include, large head (macrocephaly), build-up of fluid in brain (hydrocephalus), heart valve abnormalities, distinctive-looking facial features, an enlarged liver and spleen (hepatosplenomegaly), and a large tongue (macroglossia).
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The drug candidates of MPS I pipeline include, but are not limited to, JOT102, SB-318 and CRISPR/Cas9. Some of the companies having drugs in the MPS I pipeline are Jupiter Orphan Therapeutics Inc., Sangamo Therapeutics Inc., and CRISPR Therapeutics Ltd.
• The report provides a comprehensive understanding of the pipeline activities covering all drug candidates under various stages of development, with the detailed analysis of pipeline and clinical trials.
• Pipeline analysis of drugs by phases includes product description and development activities including information about clinical results, designations, collaborations, licensing, grants, technology, and others.
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