Apolipoprotein B-48: marker of cardiovascular risk

Apolipoproteins are essential components of lipoproteins, which are the carriers to transport the hydrophobic lipids through the water based circulatory systems of blood and lymph. One lipoprotein particle can contain several apolipoproteins and those can perform different functions. Apolipoproteins stabilize the structure of lipoproteins. They work as coenzyme factors, receptor ligands and lipid transfer carriers and thus manage their uptake in tissues and cells. Altogether they play an important and central role in the metabolism of lipoproteins.
Apo B-48 is present in chylomicrons and chylomicron remnants and plays an essential role in the intestinal absorption of dietary fats. It is synthesized in the small intestine. Apo B-48 is encoded by the same gene as of Apo B-100 and is at least generated when a stop codon (UAA) at residue 2153 is created by RNA editing. Thus Apo B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon and lacks Apo B-100's C-terminal LDL receptor binding region. ApoB-48 is so called because it constitutes 48 percent of the sequence for ApoB-100.

Deficiency of apolipoprotein B-48 induced malabsorption of fat and fat-soluble vitamins from food and led to the rare clinical disorder of abetalipoproteinemia. Overexpression of Apo B-48 led to fatty liver and liver fibrosis.
Recent studies indicate that elevated postprandial levels of chylomicrons and chylomicron remnants are associated with an increased risk for atherosclerosis. Apolipoprotein B-48 (apoB-48) is an essential component of these lipoproteins. Therefore, the measurement of increased serum Apo B- In humans Apolipoprotein B-48 (Apo B-48) is a unique protein of chylomicrons and seems to be a suitable marker to determine postprandial lipoproteins and related cardiovascular risk factors. The biotechnology company Xceltis GmbH offers an ELISA Kit for safe and rapid measurement of human Apo B-48 with an excellent precision, high sensitivity and reproducibility.
48 concentration enables understanding of the kinetics of intestine-derived lipoproteins and their relevance with regard to the increased risk of atherosclerosis and a possible life expectation.

Xceltis GmbH offers an ELISA Kit for safe and rapid measurement of human Apo B-48 with an excellent precision, high sensitivity and reproducibility.

Xceltis GmbH is a novel and ambitious biotechnology company, which offers an extensive range of ELISA Kits, combined with a high standard of customer support services. The team of Xceltis GmbH foremost objective is to assist clients to find the suitable ELISA Kit or any other product in the area of biotechnology.

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www.xceltis.de

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This release was published on openPR.