Press release
BET Inhibitors Analysis, Clinical Trials, Collaboration and Developments - Resverlogix Corp., GSK, Bristol-Myers Squibb
*Insights on pipeline segments
As per the findings of the research, most of the BET inhibitor pipeline drug candidates are being developed to be administered by oral route.
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*IC50 value and Kd of different types of BET inhibitors
In BET inhibitors, IC50 value is measured as the concentration of drug at which 50% of the target is inhibited. IC50 is a pharmacokinetic measure; the lower the IC50 of drug candidate, the lesser the desired effect, and the less likelihood of the drug to have some off-target effect. Kd is known as dissociation constant of drug. It measures the rate of dissociation of the drug and its binding affinity. Birabresib (MK8628), a BET inhibitor by Merck & Co., has IC50 value of 100nM.
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*Strategic collaborations for the development of BET inhibitors
The research finds that different companies are collaborating for the development of BET inhibitors. In January 2017, ConverGene had entered into a sponsored research agreement with the University of Maryland, Baltimore to investigate the in vivo anti-leukemic effects of ConverGene’s lead BET inhibitor drug candidates, CG223 and CG250.
Browse report at: http://bit.ly/2mQxa6b
Some of the key players developing BET inhibitors are Resverlogix Corp., GlaxoSmithKline plc, Bristol-Myers Squibb Company, and others.
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