Anti-epileptic Drugs for Pediatrics Market With Top 20 Countries data Analysis, Growth by Top Companies, Trends by Types and Application, Forecast Analysis to 2026 Mylan N.V., Cephalon, Inc., GlaxoSmithKline plc, Pfizer, Inc.

Anti-epileptics drugs for pediatrics treatment are expected to experience visible shifts in terms of demand and adoption owing to factors such as rise in global prevalence of epilepsy, increasing healthcare spending and emergence of efficacious newer anti-epileptic drugs. Furthermore, co-morbidities associated with epilepsy such as depression and anxiety are on rise and major players are investing in the research and awareness programs for reduction of these co-morbidities along with epilepsy. For instance, Sanofi, S.A. invests major amounts into awareness programs in regions with emerging economies such as Latin America, Africa, and Asia Pacific. The company offers products with price adjustments in these regions to increase the access to these treatments. The investments by major players in the pipeline over the past few years have shown positive results in terms of product launches such as Vimpat drug approvals in Europe and Japan in the treatment of partial onset seizures for UCB Pharma in 2016.

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Market Dynamics

Major market players are focusing on providing viable treatment options in patients suffering from refractory epilepsy or drug resistant epilepsy. The add-on or adjunctive therapies designed by market players offer significant positive results with relatively less side effects. This, in turn, is expected to boost the market growth rate for anti-epileptic drugs. Some notable drugs in the pipeline such as Lyrica (Pregabalin), are showing potential therapeutic effects with fewer drug interactions, improved side effect profiles, and enhanced overall safety. This addresses a major need in the AED market, since most of the older treatments such as carbamazepine, valproate, and phenytoin, although effective, have very poor safety profiles and are not well-tolerated by pediatric patients.

Newer Drug Therapies With Symptom Specific Indications Are Expected To Boost Market Growth

Epilepsy is a highly prevalent disorder, especially in emerging economies as an estimated 50 million people worldwide are suffering with epilepsy out of which almost 80% live in emerging economies as per the World Health Organization (WHO). According to the American Academy of Pediatrics, as of April 2017, epilepsy is estimated to affect 0.5% to 1% of children globally and is the most prevalent chronic condition of the central nervous system among children. According to Epilepsy Foundation, each year, around 150,000 new cases of epilepsy are reported in the U.S. and the rate of occurrence is high among young children and geriatric population. Furthermore, the Society of Neuroscience, in 2015, stated that epilepsy affected around 10.5 million children worldwide, and the types and severity of the disorder varies significantly.

The incidence and prevalence of epilepsy for children appears to be lower in developed economies and highest in rural areas of emerging economies. This is mainly attributed to the presence of FDA-approved anti-epileptic drugs in the developed economies and the vast distribution channel providing higher accessibility. Scientific and technological advances have introduced many new medications in the past decade, which are used in combination and in a personalized way by physicians for the treatment of pediatrics. The U.S. Food & Drug Administration (FDA) approved drugs, including Phenytoin (Dilantin), Carbamazepine (Carbatrol), Divalproex Sodium (Depakote), and Ethosuximide (Zarontin).

Competitors In "Anti-epileptic Drugs for Pediatrics Market"

Some major players operating in the anti-epileptic drugs for pediatrics market are Mylan N.V., Cephalon, Inc., GlaxoSmithKline plc, Janssen Pharmaceuticals, Novartis AG, Pfizer, Inc., Sanofi S.A., UCB Pharma Limited, Sunovion Pharmaceuticals Limited, Valeant Pharmaceuticals International, Inc., Zogenix, GW Pharmaceuticals, Insys, and Zynerba.

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Detailed Segmentation:

Global Anti-Epileptic Drugs for Pediatrics Market, By Drug Type:
1st Generation
2nd Generation
3rd Generation

Novel Medications And Effective Drug Therapy Options Are Expected To Boost The Market In The Forecast Period

The number of available anti-epilepsy drugs has doubled over the last few decades and nine new drugs for treatment of pediatric epilepsy were launched in the last decade, as the benefits of the medicines are greater than the subsequent side-effects from the medicine. Third generation epilepsy drugs are rapidly replacing second and first generation drugs, as they are more safe and tolerable than the previous generation drugs. The newer drugs have better efficacy, with much better pharmacokinetic profiles and fewer drug interactions than the classic first generation drugs.

For instance, the third generation drugs, UCB’s Keppra (levetiracetam) and GlaxoSmithKline’s (GSK’s) Lamictal (lamotrigine) have rapidly become commonly used drugs for first-line treatments. The anticonvulsant medications are only FDA-approved for seizure disorders among children. Also, the currently available newer anti-seizure drugs have simple pharmacokinetics and more limited effects on liver metabolism, thus driving the anti-epileptic drugs for pediatrics market.

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