|11-06-2018 07:48 AM CET - Health & Medicine||
Bioreactors Market Set Explosive Growth to 2026 Responsible Factors Discussed By Key Vendors Thermo Fisher Scientific, Inc., Merck KGaA, GE Healthcare, Pall Corporation, ZETA Holdings GmbH, Sartorius AG BBI, Solaris
Press release from: Coherent Market Insights - Medical Devices Industry
Bioreactor is an engineered or manufactured vessel that is used in the production of wide range of biological products. Industrial bioreactor is a vessel in which biochemical process is carried out using microbes and animal cells or biologically active compounds that are derived from living cells. Bioreactors are cylindrical in shape with capacity of liters to cubic meters and is the most important component involved in bioprocessing. Fermentation processes such as wine, and beer production are carried out in bioreactors. Bioreactors for large scale production of therapeutic products are made of stainless steel. In biopharmaceutical companies, small glass bioreactors are used for research and development purpose and for scale up activities. Another type of bioreactors are disposable bioreactors, which are meant for single use and hence are called as single-use bioreactors. It is generally used for extensive research and manufacturing. Bioreactors can operate in batch, fed batch, and continuous stirred tank processes. Bioreactors are used to produce therapeutics, which include monoclonal antibodies, vaccines, stem cells, and gene modified cells.
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The efficiency of single-use bioreactors has increased across pharmaceutical industries in terms of production, quality control, and procurement. Single-use bioreactors offer advantages such as consistency in production, increase in speed of manufacturing, reduced operational cost, and reduction in manufacturing time of finished dosage form, which foster growth of bioreactors market. In 2016, as per the National Centre for Biotechnology Information (NCBI), operational cost per gram of monoclonal antibody production (mAb) for single-use bioreactor is around 22% lower than conventional system, mainly due to less labor, utilities, maintenance, and waste. For commercial scale of monoclonal antibody production (mAb), conventional fed-batch bioreactors usually require 10000L – 25000L stainless steel tank to culture cells and produce yield of 2-6 g/L.
However, single-use bioreactors employ continuous cell culture supply in 500L - 2000L tank and produces 10 - 30 times higher cell density. Therefore, more quantity of products can be produced by using this single-use bioreactors, with less space and capital cost. Other factors that contribute to growth of the market include low water usage by single-use systems, less floor space requirement, and low risk of cross contamination in single-use system. Furthermore, in 2016, a case study by Cambridge Healthtech Institute stated that by using single-use (SU) bioreactors, there can be an annual savings of US$ 250,000 in water generation for injections and US$ 60,000 in labor time required to set up and cleaning of stainless steel tank. These factors are expected to drive growth of the bioreactors market over the forecast period.
Key players operating in bioreactors market include Thermo Fisher Scientific, Inc., Merck KGaA, GE Healthcare, Pall Corporation, ZETA Holdings GmbH, Sartorius AG BBI, Solaris, Praj HiPurity Systems Limited, BiOENGiNEERiNG, INC., Infors AG, and Appplikon Biotechnology, Inc.
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Bioreactors market is segmented on the basis of bioreactor type, usage, capacity, end user, and geography.
By Bioreactor type-
Stainless Steel Bioreactor
Large scale production
Full scale production
5L – 20L
20L - 200L
200L – 1500L
By End Users-
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