Amyotrophic Lateral Sclerosis Pipeline Drugs Assessment: Clinical Trails Analysis, Player Profiles, Collaborations, Key Targets, Geographic Focus, and Data Publications, 2018

Amyotrophic Lateral Sclerosis Pipeline Drugs Assessment Overview:

Amyotrophic lateral sclerosis is the most common degenerative disease of the motor neuron system, enables destroy nerve cells and causes disability. Amyotrophic lateral sclerosis is known as Lou Gehring’s disease.
Amyotrophic lateral sclerosis often begins with muscle twitching and weakness in a limb, or slurred speech. Afterwards, may affects the control of the muscles involved in movement, speaking, eating and breathing. There is no cure for the disease and eventually disease is fatal.

The disease is inherited in 5% to 10% of cases and rest is unknown etiology. Researchers are studying several possible causes including gene mutation, chemical imbalance, and protein mishandling and disorganized immune response. Amyotrophic lateral sclerosis is difficult to diagnose, because it mimics various neurological disease symptoms. Generally ALS diagnosed using electromyogram, nerve conduction study, MRI, spinal tap and muscle biopsy. Blood and urine test are performed to sort out the other possible signs and symptoms.

Two FDA approved drugs are available in the market, namely Riluzole and endaravone. Various therapies are available to reduce the symptoms of the disease.

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Segmentation:
The pipeline drugs are segmented based on route of administration, trial phase, and company
By route of administration, amyotrophic lateral sclerosis pipeline drugs are segmented into
• Oral
• Parenteral
• Others
By trial phase, amyotrophic lateral sclerosis pipeline drugs are segmented into
• Pre-clinical phase
• Phase-I
• Phase II
• Phase-III
By company, amyotrophic lateral sclerosis pipeline drugs are segmented into
• Mallinckrodt Pharmaceuticals
• ASTELLAS PHARMA INC. (JAPAN)
• REVALESIO CORPORATION (U.S.)
• Amylyx Pharmaceutical Corp. (U.S.)
• Mitsubishi Tanabe Pharma Corporation (Japan)
• AB Science (France)
• H. Boehringer Sohn AG &Co. KG (Germany)

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Space Analysis:
Most of the pipeline drugs for treatment of amyotrophic lateral sclerosis pipeline are at preclinical stages. Companies with pipeline molecules mostly focused on neuro protection, immunomodulation, and glutamate excitotoxicity blockers for the treatment of amyotrophic lateral sclerosis.
• In November 2017, U.S. Food and Drug Administration has given clearance of the clinical investigation of Biohaven Pharmaceutical’s sublingual lead, BHV-0223 for the treatment of amyotrophic lateral sclerosis.
• In September 2017, U.S. Food and Drug Administration granted orphan drug designation to Revalesio’s investigational drug RNS60 to treat Amyotrophic Lateral Sclerosis (ALS).

Report Description:
Amyotrophic Lateral Sclerosis Pipeline Drugs Assessment report studies the various therapeutics under clinical development for uterine fibroids treatment along with targets for various drug candidate. The report provides plethora of information pertaining to trail phases, companies involved in the uterine fibroids pipeline drugs development. This report studies the dynamics of the Amyotrophic Lateral Sclerosis Pipeline Drugs i.e. drivers, challenges, and opportunities which are significantly impacting the product development. The report provides various information pertaining the clinical trials such as designation, grants, patents, and technology among others. Moreover, the report on uterine fibroids pipeline drugs assessment comprehensively presents the geographic location, trial status information along with key players involved in the therapeutics development.

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Key Features of the Report:
• Provides the information related to universities and research institutes working in the therapeutics development
• Report comprehensively covers the all active and discontinued studies
• Studies the entire pipeline with special emphasis on companies actively involved in the therapeutics development
• Presents the prominent targets for drug development in each stage of clinical trial
• Provides the in-depth analysis of each drug candidates in the clinical trial phases

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