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Press Releases from Trevigen, Inc. (9 total)

02-01-2010 | Sports
Trevigen, Inc.

HT PARP in vivo Pharmacodynamic Assay II

Trevigen announces a validated assay, with higher sensitivity and pre-coated antibody plates to measure the effectiveness of PARP inhibitors in cell and tissue lysates for anticancer drug screening. Pharmacodynamic (PD) assays have recently been developed and employed early in the drug screening process to assess the ability of potential drug candidates to affect molecular targets. These assays have the advantages of performing molecular proof-of-concept investigations at an early stage such as

Trevigen Releases CultreCoat® Cell Adhesion Assays

Trevigen announces the release of seven new coated well assay kits for cell adhesion studies. A cell’s ability to adhere to extracellular matrix (ECM) proteins is a necessary precursor to cell invasion, and this process also modulates morphogenesis, wound healing, proliferation, differentiation, and survival. Researchers studying cancer cell behavior or developing cancer therapeutics study cell adhesion with various proteins, recognizing that manipulation of cell adhesion to the extracellular environment may

Trevigen Announces the First Standardized Comet Assay Electrophoresis System

The comet assay is the only direct method for the detection of DNA damage in cells. It is used in cancer research, in genotoxicity studies on environmental mutagens, and for screening compounds for cancer therapeutics. Based on single cell gel electrophoresis in a controlled pH environment, the assay allows the integrity of stained nuclear DNA to be examined and measured. Until now, a lack of standardization in electrophoresis equipment, control cells,

Trevigen Announces a Highly Sensitive, Fluorescent, One Hour PARP Inhibition Ass …

Poly(ADP-ribose) polymerase, through ribosylation of nuclear proteins, converts DNA Damage into intracellular signals that actuate either DNA repair or cell death. The development of inhibitors to PARP is of ever increasing interest in the drug discovery community since they can be used as modulators of DNA repair mediated resistance to cytotoxic cancer therapeutics. Until now, commercially available PARP assay kits required multiple steps and were time consuming. Trevigen overcomes these

Trevigen announces the release of Four New Assay Kits for 3-D Cell Proliferation

Many scientists are converting from growing cells in a traditional 2-D Monolayer on plastic surfaces with tissue culture medium to “3-D” Culture. In 3-D Culture, cells are grown in a microenvironment of specialized proteins which mimics in vivo conditions and allows the cells to organize into complex structures rather than uniform monolayers. Various types of cells require different specialized proteins for optimal growth conditions and these extracellular matrices can play

Trevigen Releases the First Standardized 3-D Culture Cell Harvesting Kit

Many scientists are converting from growing cells in a traditional 2-D monolayer on plastic surfaces with tissue culture medium to “3-D” Culture. In 3-D Culture, cells are grown in a microenvironment of specialized proteins which mimics in vivo conditions and allows the cells to organize into complexstructures rather than uniform monolayers. Further, 3-D Cultures are grown on extracellular matrix proteins such as basement membrane extract and laminin I, which are known

Trevigen Launches LDEV Free Basement Membrane Extract

Trevigen launches LDVE Free Basement Membrane Extract within its Cultrex® product line of Cell Differentiation and Angiogenesis products. Basement Membrane Extract (BME) can be used for promotion and maintenance of a differentiated phenotype in a variety of cell cultures including primary epithelial cells, endothelial cells, and smooth muscle cells. Trevigen’s LDVE Free designation means that in addition to standard sterility, endotoxin and MAP testing, the BME is tested by

Trevigen Launches Cultrex® 24 Well Cell Invasion Assay Kits

Trevigen's Cultrex® 24 Well Cell Invasion Assay kits quantify the degree to which invasive cells penetrate either basement membrane extract, collagen I, collagen IV, or laminin I, in vitro. The kit uses Calcein AM to assay invasive properties of cells in response to stimulators or inhibitors. Utilizing a simplified Boyden chamber design with individual 8 µm polyester membrane inserts, the 24 well format allows users to independently coat

Trevigen Launches High-Throughput PARP/Apoptosis Assays

Trevigen launches High-Throughput PARP/Apoptosis Assays ideal for measuring the activity of PARP in 96-well plates. Cell extracts can be obtained using our newly-developed, higher-throughput procedure before, during and after apoptosis induction. During apoptosis, PARP-1 which catalyzes the NAD dependent addition of poly (ADP-ribose) (PAR) onto various cytoplasmic and nuclear proteins, is cleaved from its enzymatically active form (about 116 kDa), to its inactive form (85 kDa). The HT PARP/Apoptosis

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