Press release
YMC-Triart Prep - Application Note: Separation of structurally similar peptides at pH ≥ 7
Reversed phase chromatography is undoubtedly the most powerful method for peptide purification. In order to improve the cost effectiveness of industrial scale peptide purifications, YMC has developed a new hybrid silica base and a novel bonding technology to improve process efficiencies and increase column life time.The new hybrid silica base, named YMC-Triart, was successfully prepared using micro-reaction flow technology. This allows the production of completely spherical, porous beads with a layered hybrid structure.
Compared to conventional silica based materials, the new hybrid particles show an enhanced stability in alkaline pH mobile phases, allowing a wider flexibility in separation conditions over an extended pH range. In addition, the new hybrid silica gels can be cleaned in place (CIP) with NaOH-containing buffers. This improves packed column life-time in peptide purification processes.
Separation of angiotensins
Human angiotensin II and III contain the same seven amino acid sequence. Angiotensin II differs from angiotensin III only by an additional N-terminal aspartate.
Structurally similar peptides such as angiotensin II and III can be difficult to separate under the low pH conditions that are typically used for peptide separations. With the increased pH stability of YMC-Triart, resolution can be increased by using neutral to alkaline pH conditions.
YMC-Triart C8-L is available in prepacked columns and in bulk. If you are interested in more information or if you would like to test a scout column or a sample please contact:
From headquarters located in Kyoto, Japan, YMC has gradually and consistently matured to a level of international recognition, specifically within the pharmaceutical and biotech world, as one of the leading suppliers of analytical and process-scale silica-based stationary phases for High Performance Liquid Chromatography, preparative equipment, custom purification and method development. New: Micro Reactor / Flow Chemistry scalable to production scale!
Qualified technical support and backup is available through operations in Japan, the United States (for the "Americas"), India, China and Germany (for Europe, Africa and the Middle East). www.ymc.de
YMC Europe GmbH
Frau Dr. Britta Blödorn
Schöttmannshof 19
46539 Dinslaken
Telefon: 02064-427-271
E-Mail: bloedorn@ymc.de
www.ymc.de
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